Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

2021-05-28

2021

Kalogera Vasiliki

Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελένη Κυρίτση, Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, Τ.Ε.Ι. Αθήνας

Επίδραση των επιπέδων της 25-υδροξυ-βιταμίνης D στην ανάπτυξη σοβαρής στένωσης αορτικής βαλβίδας

Greek

Effect of serum 25-hydroxyvitamin D levels on the development of severe aortic valve stenosis

Introduction: Aortic valve stenosis is the most common valvulopathy undergoing transcatheterial and surgical repair. Patients with severe aortic stenosis have non- acceptable quality of life in most cases. Vitamin D is a lipid soluble molecule with anti-inflammatory properties; it has also shown a positive effect in reducing classic risk factors for coronary artery disease and cardiovascular morbidity in general.
Objective: To investigate any possible association between serum 25-hydroxyvitamin D levels and severe aortic valve stenosis
Materials and methods: Sixty (60) patients in total from two centers (Evaggelismos General Hospital, Athens, Greece and Ippokrateio General Hospital, Athens, Greece) were recruited for this study. All participants underwent transthoracic cardiac ultrasound; half of them (30) had severe aortic stenosis and the rest of them had not aortic valve stenosis. Serum 25-hydroxyvitamin D levels were measured in all subjects using electrochemiluminescence-based assay (Elecsys Vitamin D Total, Roche Diagnostics, Mannheim, Germany).
Results: Patients were divided into two groups: aortic stenosis group and control group. Statistical analysis resulted in no significant association between Vitamin D levels and severe aortic valve stenosis (p=0,519). Mean vitamin D levels in patients with severe aortic valve stenosis were slightly higher than in control group. In addition, statistical analysis of some clinical characteristics (dyslipidemia, coronary artery disease and coronary artery disease family history) resulted in no significant association among them and severe aortic valve stenosis (p>0,05).
Conclusions: No association between serum Vitamin D and severe aortic valve stenosis was found in this study. Small sample size or molecular and genetic factors could have contributed to that null result. Further studies with more participants are necessary in order to conclude whether these two variables are correlated.

Health Sciences

Vitamin D, Aortic valve stenosis, Rabbit

No

0

Yes

167

138

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https://pergamos.lib.uoa.gr/uoa/dl/object/2946240