Faculty of Medicine
Library of the School of Health Sciences

2021-05-29

2021

Mentesidou Anastasia

Χρήστος Σαλάκος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Χρούσος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χριστίνα Κανακά - Gantenbein, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αλκιβιάδης Κωστάκης, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευστάθιος Αντωνίου, Αναπληρωτής Καθηγητή, Ιατρική Σχολή, ΕΚΠΑ
Φλώρα Μπακοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Γιαπιτζάκης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Διερεύνηση της σχέσης των διαμαρτιών του μεσορχέου με την κρυψορχία μετά από προγεννητική αναστολή των ανδρογόνων: Πειραματική μελέτη σε επίμυες

Greek

Morphologic alterations of the genital mesentery implicated in testis non-descent after in utero exposure to antiandrogens: Experimental study in rats

Introduction: There is an endless debate on whether androgens mediate testis descent through developmental changes in the gubernacular or the cranial suspensory ligament. The aim of the present study was to investigate the relation of any possible morphologic changes in the genital mesentery, that is, the system of genital peritoneal folds including the gubernacular and cranial suspensory ligaments, with the event of testis non-descent in rats prenatally exposed to the antiandrogen flutamide.
Materials and Methods: Time-pregnant Sprague-Dawley rats received flutamide (100 mg/kg/d) or vehicle subcutaneously on gestational days 16-17. Flutamide-treated male offspring (n=67), and vehicle-treated male (n=34) and female (n=28) offspring were surgically explored under microscope on postnatal day 50. Testicular position was examined bilaterally. Dimensions of genital mesentery parts were also assessed bilaterally. Association of flutamide-induced morphologic changes with descended (n=61) and undescended (n=50, 33 cryptorchid and 17 ectopic) testes was investigated with logistic regression analysis.
Results: The male genital mesentery comprised a cranial and a caudal fold converging on the vas deferens. Flutamide resulted in enlarged cranial and reduced caudal folds. Of all flutamide-induced alterations, the increased length of the posterior fixation of the cranial fold and the decreased length of the gubernacular ligament of the caudal fold were found to independently increase the odds of testis non-descent. Testicular ectopy, unlike cryptorchidism, was associated with a short gubernacular ligament only. The female genital mesentery consisted of a cranial fold only.
Conclusions: The findings of the present study showed a combined contribution of both cranial and caudal folds of the genital mesentery to testis non-descent, through an abnormally long mesentery root and an abnormally short gubernacular ligament, respectively. Inhibition of male-specific development of the genital mesentery with flutamide did not result in a feminized architecture.

Health Sciences

Cryptorchidism, Testis ectopy, Testis descent and non-descent, Genital mesentery, Mesorchium, Processus vaginalis, Tunica vaginalis, Cranial suspensory Ligament, Gubernaculum, Experimental model of cryptorchidism in rats, Prenatal androgen blockade, Sexual dimorphism, Pediatric urology, Pediatric surgery, Experimental surgery

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https://pergamos.lib.uoa.gr/uoa/dl/object/2946321