Unit:
Speciality Infectious DiseasesLibrary of the School of Health Sciences
Author:
Damoulari Christina
Supervisors info:
Ευάγγελος Ι. Γιαμαρέλλος-Μπουρμπούλης, Καθηγητής, Ιατρικής Σχολής, Ε.Κ.Π.Α
Γεώργιος Δημόπουλος, Καθηγητής, Ιατρικής Σχολής, Ε.Κ.Π.Α
Καρολίνα Ακινόσογλου, Επίκουρη Καθηγήτρια, Ιατρικής Σχολής, Πανεπιστημίου Πατρών
Original Title:
Tο υδρόθειο στην πρόγνωση της νόσου COVID-19
Translated title:
hydrogen sulfide in prognosis of covid-19
Summary:
Hydrogen sulfide (H2S) is found in the form of a gas and is derived from the biosynthesis of L-cysteine, which is depended on the activity of three enzymes: cystathionine γ-lyase (CSE), cystathionine β-synthetase (CBS) and 3 -mercaptopyrostaphyl sulfate transferase (3-MST). The pathway begins with homocysteine and more than one enzymatic pathways are followed for the production of hydrogen sulfide. Hydrogen sulfide has multiple roles in pathophysiology including neurotransmission, mediation of proinflammatory processes, cell protection against oxidative stress and promotion of angiogenesis. It is metabolized as an inorganic substrate while in terms of signaling, it interacts with multiple types of molecular targets. It plays an important role in inflammation. Multiple studies show that the hydrogen sulfide molecule has both pro-inflammatory and anti-inflammatory effects. It also plays a significant role in respiratory infections. In COVID-19 in particular, it appears as a prognostic indicator for the outcome of these patients. Specifically, the results from a study involving 74 patients, have shown that the highest value of serum hydrogen sulfide (greater than 150.44 μM) at patient’s admission, and at the same time the lowest fold change (less than 36%) between days 1 and 7 play an important role fot the outcome of these patients on day 28. In addition, assays were performed between patients' serum hydrogen sulfide and biochemical markers such as tumor necrosis factor-α, interleukin-6, procalcitonin and c-reactive protein. There is a positive correlation between the absolute lymphocyte count and hydrogen sulfide as well as a negative correlation between interleukin-6 and hydrogen sulfide. These results support the prognostic value of hydrogen sulfide as an independent prognostic indicator for the outcome of COVID-19 disease, with a view to conducting larger cohorts.
Main subject category:
Health Sciences
Keywords:
Hydrogen sulfide, Covid-19, Interleukin-6, IL-6, Lympocytes, Procalcitonin, PCT, Tumor necrosis factor-α, TNFα
