Unit:
Κατεύθυνση Ακοολογία–ΝευροωτολογίαLibrary of the School of Health Sciences
Author:
Ioannidis Athanasios
Supervisors info:
Μπίμπας Αθανάσιος, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
Δερβεντζή Αναστασία, Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Γαζούλη Μαρία, Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Original Title:
Ωτοπροστατευτικοί παράγοντες στη βαρηκοΐα από θόρυβο
Translated title:
Otoprotective agents in noise-induced hearing loss
Summary:
Theoretical Background: The effect of noise in modern industrial societies is a major problem for people’s quality of life. Especially industrial workers, men that work in the military, musicians and in general people exposed in noise seem to have more frequently hearing loss. There are many studies on a range of drugs that seem to protect against noise-induced hearing loss.
Aim: The aim of this study is to review a wide range of clinical trials and literature that have been recorded the last ten years on this topic in order to capture effective and beneficial drug options that can protect against noise-induced hearing loss.
Method: In the present essay, a narrative review was performed using the PubMed, Cochrane Library and Google Scholar databases. Based on this search and restriction of the articles that are included in the last decade, are available in English and in full text 526 articles emerged. Then, based on further content filtering, exclusion of articles that did not refer to the preventive action of pharmaceutical 17 articles were used to write the paper. The structure of the text was checked based on the checklist for systematic review of PRISMA.
Results: Several studies and literature reviews have been conducted in the last decade but no protective pharmaceutical protocol has been established in noise exposure. However, factors that have been tested and could be part of this effort include acetylcysteine, ginseng, ebselen, the ACEMg complex, metformin, nifedipine, activated protein C, and propofol.
Conclusions: ACEMg plays a role in maintaining hearing in noise-induced hearing loss according to animal experiments. N-acetyl-cysteine and more recently ebselen as antioxidants have shown promising results in prevention of noise-induced hearing loss and need further documentation to be used in daily practice. Ginseng does not have a sufficiently proven otoprotective effect and studies to date have not shown significant results. Moreover, silymarin requires further study to prove its otoprotective effect. Metformin is a widely used drug whose otoprotective effect requires further study to determine. ATP is involved in the prevention of noise hearing loss. Based on this, nifedipine may have a prophylactic effect against noise-induced hearing loss. The systemic administration of propofol and the intraperitoneal injection of APC have shown otoprotective effect against noise hearing loss, however, their applicability in daily practice is questionable.
Main subject category:
Health Sciences
Keywords:
NIHL, Noise-induced hearing loss, Noise exposure, Noise, Otoprotectants, Pharmacological agents, Pharmaceutical prevention, Otoprotection strategy
