Speciality Infectious Diseases
Library of the School of Health Sciences

2021-07-22

2021

Dareioti Maria

Ευάγγελος Ι. Γιαμαρέλλος-Μπουρμπούλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χαράλαμπος Γώγος, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Πατρών
Ελένη Μάγειρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Αναστολή ιντερλευκίνης-1 και αντιφλεγμονώδεις αποκρίσεις στη νόσο COVID-19

Greek

Interleukin-1 inhibition and anti-inflammatory responses in COVID-19 disease

This thesis aims at studying the inhibition of Interleukin-1 on inflammation caused by COVID-19; systemic inflammatory reaction is a profound characteristic of the disease. In patients, there are high concentrations of pro-inflammatory cytokines that can lead to acute respiratory distress (ARD) syndrome. Immunologically, this can be caused either by macrophage activation syndrome or by immune system dysfunction due to decreased expression of the HLA-DR antigen receptor in circulating monocytes. These immune responses start quite early in patients with lower respiratory tract infections and are progressively enhanced. This is due to the early release of interleukin-1 from the epithelial cells of the lungs that have been infected with the virus. However, not all patients will have ARD syndrome. Early identification of these patients and initiation of interleukin-1 (IL-1) immunoregulatory therapy may prevent acute respiratory failure.

Health Sciences

Interleukin-1, COVID-19

No

0

Yes

38

40

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https://pergamos.lib.uoa.gr/uoa/dl/object/2958029