Department of Chemistry
Library of the School of Science

2021-07-30

2021

Koutsikou Theodora

Ε. Ευθυμιάδου, Επίκουρη Καθηγήτρια, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Π. Κυρίτσης, Καθηγητής, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ε. Λιανίδου, Καθηγήτρια, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Κ. Μεθενίτης, Αναπληρωτής Καθηγητής, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Γ. Μήτρικας, Ερευνητής Β’, Ινστιτούτο Επιστήμης Υλικών, Ε.Κ.Ε.Φ.Ε «Δημόκριτος»
Χ. Μητσοπούλου, Καθηγήτρια, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Π. Μπουζιώτη, Ερευνήτρια Α’, Ινστιτούτο Ραδιοϊσοτόπων/Ραδιοδιαγνωστικών Προϊόντων, Ε.Κ.Ε.Φ.Ε «Δημόκριτος»

Σύνθεση, χαρακτηρισμός και βιολογική αξιολόγηση νάνο-δομών επισημασμένων με ραδιοϊσότοπα εκπομπής γ-φωτονίων και ποζιτρονίων

Greek

Synthesis, characterization and biological evaluation of radiolabeled with gamma-photon and positron nano-containers

Over the past decade, advances in the design of controlled drug delivery systems have led to a tremendous growth in the treatment of many diseases. In this study a kind of core-shell composite nano-carrier with an inner cavity was formed by emulsion polymerization from a variety of monomers with specific sensitivities. The small size of this structure allows to nanocarriers to cross various biological barriers and achieve passive targeting through the enhanced permeability and retention effect (Enhanced Permeability and Retention Effect, EPR effect), which facilitates the release of drugs particularly into the desired tissues without causing adverse treatment reactions, such as the treatment of cancer. The synthetic process consists of two steps. In the first step a non-toxic spherical nucleus is synthesized and in the second step the shell is formed from a combination of monomers. Each monomer has a unique sensitivity such as pH, temperature and sensitivity to the redox environment. Taking advantage of this behavior and removing the core, NCs have been set up to respond to an external stimulus that triggers drug release in a controlled manner. The main advantage of this work in terms of the synthetic process, is the inside of the spheres formed during the formation of the shell, allowing the small molecules of biological interest (inhibitors) to be hosted and at the same time released into the tumor area. In conclusion, this paper presents the synthesis and characterization of hollow nanostructures (NCs), with different sensitivities, as potential drug delivery systems for the treatment of cancer traced with radioactive isotopes such as 68Ga and 99Tc.

Science

selective targeting, cancer cells, inhibitors, multi-sensitive nano-containers, radiolabeling

Yes

15

Yes

136

185

File access is restricted until 2026-08-02.

https://pergamos.lib.uoa.gr/uoa/dl/object/2959008