Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Karampelas Michail
Dissertation committee:
Μπρούζας Δημήτριος -Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπακωνσταντίνου Δημήτριος - Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεωργάλας Ηλίας - Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυμιωνής Γεώργιος - Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χατζηστεφάνου Κλειώ - Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δρούτσας Κωνσταντίνος - Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χατζηράλλη Ειρήνη - Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συγκριτική ποσοτική και μορφομετρική μελέτη της απόκρισης των αποκολλήσεων μελάγχρου επιθηλίου σε έδαφος υγράς ηλικιακής εκφύλισης ωχράς μετά από θεραπεία με aflibercept και ranibizumab
Translated title:
Morphometric analysis of fibrovascular pigment epithelial detachments treated with ranibizumab and aflibercept
Summary:
PURPOSE: To assess fibrovascular PEDs and their response to two different anti-VEGF agents using OCT morphometric analysis. METHODS: 73 consecutive, treatment-naïve eyes with fibrovascular PED (>125 µm) treated with ranibizumab or aflibercept were retrospectively included. A custom-made software was used to manually segment and calculate PED maximum height, base area, volume and internal reflectivity at baseline, after 3 injections and one year. RESULTS: VA change was 2 ETDRS letters ± 7.6 after 3 injections and 3.2 ETDRS letters ± 10.3 at 1 year. There was no significant difference between VA changes amongst the two drugs. At one year, anti-VEGF treatment resulted in a mean reduction of 125 μm in maximum PED height, of 2.26 mm2 in base area and of 0.54 mm3 in volume with a corresponding increase in reflectivity. These changes were more prominent in the aflilbercept group. The observed PED and VA changes at year 1 were strongly correlated with their values at baseline and after 3 injections. CONCLUSIONS: Anti-VEGF treatment resulted in a reduction of all PED dimensions and a corresponding increase in optical reflectivity. Higher, larger and more hypo-reflective PEDs demonstrated a better anatomical response , especially with aflibercept, but this was not correlated with VA.
Main subject category:
Health Sciences
Keywords:
Retina, Pigment Epithelial detachment, Optical coherence tomography, Age related macular degeneration
Number of references:
101
