Unit:
Κατεύθυνση Ανάπτυξη Νέων Φαρμάκων: Έρευνα, Κυκλοφορία και ΠρόσβασηLibrary of the School of Health Sciences
Supervisors info:
Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ηλίας Κοττέας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Έλενα Γκόγκα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Emerging treatment pathways in colorectal cancer
Translated title:
Emerging treatment pathways in colorectal cancer
Summary:
Colorectal cancer (CRC) represents the third most common and second most lethal type of cancerworldwide. Over the past decades, many studies and clinical trials have led to advances in systemic therapy of CRC, including chemotherapy, targeted therapy, and immunotherapy. Chemotherapy-based regimens affect cancer as well as normal cells, leading to considerable toxicity. Multiple signaling pathways, linked to the development and progression of CRC, constitute targets for CRC therapy. In this review, we describe currently available systemic therapies for the treatment of colorectal cancer. Then, we report emerging systemic therapies and novel therapeutic approaches for patients with CRC, including therapeutic potential targets of the Wnt/β-catenin signaling pathway, EGFR pathway, VEGF/VEFGR pathway, HGF/C-MET pathway, immune checkpoint inhibitors, vaccines and other systemic therapies.
Main subject category:
Health Sciences
Keywords:
Colorectal cancer, CRC, Pathways
File:
File access is restricted only to the intranet of UoA.
EMERGING TREATMENT PATHWAYS IN COLORECTAL CANCER 2020.pdf
1 MB
File access is restricted only to the intranet of UoA.
