Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Zervas Alexandros
Dissertation committee:
Ισμήνη-Νίκη Δοντά, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σοφία Μητάκου, Καθηγήτρια, Φαρμακευτική Σχολή, ΕΚΠΑ
Ευστάθιος Χρονόπουλος, Αν. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παρασκευή Μουτσάτσου-Λαδικού, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λέανδρος-Αλέξιος Σκαλτσούνης, Καθηγητής, Φαρμακευτική Σχολή, ΕΚΠΑ
Ευανθία Κασσή, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βασίλειος Νικολάου, Επ. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Εκτίμηση της προστατευτικής δράσης του εκχυλίσματος επιτραπέζιας ελιάς στην οστική πυκνότητα στο πρότυπο οστεοπόρωσης του ωοθηκεκτομημένου επίμυος
Translated title:
The effect of table olive wastewater extract administration on the ovariectomised rat model of osteoporosis
Summary:
Recent efforts for alternative non-pharmaceutical treatments for postmenopausal osteoporosis are focused on nutritional measures. The aim of this study was to investigate the effect of table olive wastewater extract (OE) administration on bone mineral density (BMD) and biomechanical strength in ovariectomized rats. Thirty mature 10-month-old female Wistar rats were separated into 3 groups of ten; Control, Ovariectomized (OVX) and OVX+OE. BMD was measured before ovariectomy, 3 and 6 months afterwards. At the end of the study, blood, both femurs, internal organs and abdominal fat were collected. After the first trimester, the percentage changes from baseline of the total and proximal tibial BMD of the OVX+OE group were both higher compared to the OVX group (p<0.005). Similar results were found after the first semester, when the percentage changes from baseline of the total and proximal tibial BMD of the OVX+OE group were both higher compared to the OVX group (p<0.005). Biomechanical testing of the femurs did not reveal any statistically significant difference between the groups. Body weights throughout the study, abdominal fat ratios to final body weight, blood results (alanine aminotransferase; ALT, Gamma-glutamyltransferase; γ-GT, total cholesterol, high-density lipoprotein; HDL-cholesterol, low-density lipoprotein; LDL-cholesterol, calcium, phosphorus) were within normal limits and did not show any significant difference between the treated and untreated groups. As a conclusion, the administration of table olive wastewater extract for 6 months protected tibial BMD loss in comparison to the untreated OVX group without causing adverse effects.
Main subject category:
Health Sciences
Keywords:
Rat, Οsteoporosis, Οvariectomy, Βone mineral density, Οlive extract
Number of references:
135
