Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Γεράσιμος Φιλιππάτος, Καθηγητής, Ιατρική Σχολή, EKΠΑ
Ιωάννης Παρίσης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιγνάτιος Οικονομίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Ηλιόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρίνα Μαντζουράνη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ευτυχία Πολυζωγοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση των ορμονών του λιπώδους ιστού σε ασθενείς με κολπική μαρμαρυγή
Translated title:
The role of adipokines in patients with atrial fibrillation
Summary:
Background. Adipose tissue dysfunction results in dysregulated adipokines production increasing cardiovascular risk. The expression of more non-cardioprotective and less cardioprotective adipokines contributes to arrhythmiogenesis through structural and electrical heart remodeling. The aim of this study was to calculate resistin, visfatin, visfatin, apelin, omentin-1 and adiponectin in patients with atrial fibrillation (AF) and without AF investigating any potential correlation of these factors with the presence of the arrhythmia and to create a more detailed metabolic profil of this population.
Methods. Overall, 100 patients (50 with AF and 50 without AF) were included and six hormones were studied in all patients. Demographic characteristics and cardiovascular risk factors were recorded. In turn, venous blood samples were collected and transthoracic echocardiography was performed. Adipokines plasma levels were measured by the Elisa method.
Results. Compared to non-AF patients, adiponectin, resistin, visfatin and chemerin levels were increased in AF patients whereas omentin-1 and apelin levels were decreased. However, these differences were significant only for apelin, adiponectin and visfatin. ROC curve and multivariate statistical analysis showed that apelin was most strongly correlated with the arrhytnia among the other measured adipokines. Moreover, NT-proBNP, left atrial (LA) size and aorta (Ao) diameter had also significant discrimination ability on the presence of the arrhythmia. A substantial cut-off value of 200pg/ml for apelin derived from the direct comparison to a control without AF group was displayed. The cut-off values for NT-proBNP, LA size and Ao diameter were 90pg/ml, 35.5mm and 35.5mm, respectively. Notably, the risk of AF was multiplied when apelin levels <200pg/ml were combined with ≥1 of the following criteria: (1) NT-proBNP >90pg/ml, (2) LA size >35.5mm and (3) Ao diameter >35.5mm.
Conclusions. In AF, adiponectin and visfatin levels were significantly increased while apelin levels were significantly decreased demonstrating a convincing link between adipose tissue dysfunction and the arrhytmia. Of them, apelin was by far most strongly associated with the presence of AF. The cut-off value of 200pg/ml for apelin was displayed and the AF risk increased when apelin beyond this level was combined with ≥1 of the following criteria: (1) NT-proBNP >90pg/ml, (2) LA size >35.5mm and (3) Ao diameter >35.5mm. Adipokines might presumably have a role as biomarkers infiltrating patients at higher risk for developing the arrhythmia.
Main subject category:
Health Sciences
Keywords:
Adipose tissue, Adipokines, Atrial fibrillation
Number of references:
126
File:
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MARIA VELLIOY PhD.pdf
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