Specialty Nanomedicine
Library of the School of Health Sciences

2021-11-29

2021

Athanasiadou Virginia

Καραλής Ευάγγελος, Επιβλέπων, Επίκουρος Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Ευσταθόπουλος Ευστάθιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δεμέτζος Κωνσταντίνος, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ

Stem cells: applications and in vivo kinetics

English

Stem cells: applications and in vivo kinetics

The primary purpose of this thesis was to provide a general overview of stem cell kinetics and current applications in the medical field. It also discussed regulatory issues and the possibility of using stem cells in the future to treat a number of diseases such as cancer and diabetes. It is possible to define cell kinetics as a collection of molecular mechanisms that regulate the proliferation and differentiation of somatic cells. The authors demonstrate and discuss a wide range of "kinetic" behaviors as defined by them. Pluripotent stem cells come in a variety of forms, including embryonic stem cells, adult stem cells, multipotent stem cells, and induced pluripotent stem cells. Exosomes and embryonic stem cells are two examples of the types of compounds that fall into this category. In addition, this thesis discusses recent developments in stem cell integration and nanotechnology that are of particular interest. Advances in nanotechnology have allowed researchers to design and fabricate biocompatible and biodegradable nanostructures that mimic the physical interactions between stem cells and niches while upregulating the molecular pathways that control stem cell fate. It is critical to accurately characterize the cells (phenotype and genotype) both before and during the scaling process to ensure that "quality" is maintained throughout the production scaling process. To determine if the cells are suitable for human clinical use, the potency of the cells must be considered as a critical parameter. Research using only frozen fertilized eggs represents a significant advance in the field of genetics. Although stem cell research has yielded promising results both in vitro and in vivo, the clinical application of stem cells has not yet been realized. In order to reduce the number of animals used for drug testing, stem cell testing, e.g., using tissue-specific human stem cells, could be performed instead of animal testing.

Health Sciences

Stem cells, Applications, Kinetics, Nanotechnology

Yes

2

Yes

99

53

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https://pergamos.lib.uoa.gr/uoa/dl/object/2967428