Κατεύθυνση Ιατρική Γενετική: Κλινική και Εργαστηριακή Κατεύθυνση
Library of the School of Health Sciences

2021-12-01

2021

Aggelaina Kalliopi

Ιωάννα Τραίγκερ-Συνοδινού, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Φρυσίρα Έλενα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βρεττού Χριστίνα, Ε. ΔΙ. Π, Ιατρική Σχολή, ΕΚΠΑ

Διερεύνηση μη-συνδρομικής ανδρικής υπογονιμότητας

Greek

Investigation of non-syndromic male infertility

BACKGROUND: Infertility is defined as a disease characterized by failure to achieve
a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. It
affects up to 15-20% of couplesglobally. Normal functioning of the male reproductive
system is biologically mostly dictated by the hypothalamic–pituitary–gonadal axis.
The origins of male infertility can be divided into three groups: pre-testicular,
testicular and post-testicular.
AIM: This study aimed to critically examine the existing literature relevant to the
genes associated with non-syndromic male infertility, look into the categories into
which these genes have been grouped and identify the most important ones for
further discussion.
METHODOLOGY: A bibliographic review of scientific publications was performed to
carry out this study. Search engines used included PubMed, Google Scholar,Med of
Science and other biomedical databases.
RESULTS: The numerous genes associated with non-syndromic male infertility can
be grouped into the following categories, according to the level of hormonal axis
affected by the gene: pre-testicular, testicular και post-testicular. Function disorders,
originating in the hypothalamus–pituitary, are grouped as pre-testicular disorders,
disorders related with testes dysfunctions during spermatogenesis are grouped as
testicular, while disorders that affect the stages after spermatogenesis are grouped
as post-testicular. Genes associated with an abnormal number of spermatozoa
following semen analysis have been a focus of this study review.
CONCLUSION: Collection and further grouping of the available data from the global
databases, related to non-syndromic male infertility, should constitute the central
focus of further research.

Health Sciences

Μale infertility, Νon-syndromic, Τesticular

No

0

Yes

141

87

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https://pergamos.lib.uoa.gr/uoa/dl/object/2967469