NKUA research material

Controlled ovarian hyperstimulation for IVF: Impact on ovarian, endometrial and cervical cancer-A systematic review and meta-analysis

English

background: In response to the ongoing debate on the long-term effects of assisted reproduction technologies, such as IVF, we systematically reviewed and meta-analyzed available evidence on the association between controlled ovarian hyperstimulation for IVF and risk of ovarian, endometrial and cervical cancer. methods: Eligible studies were identified and pooled effect estimates for relative risk (RR) were calculated by cancer type among two reference groups (general population or infertile women), through fixed- or random-effects models as appropriate. results: Nine cohort studies were synthesized, corresponding to a total size of 109 969 women exposed to IVF, among whom 76 incident cases of ovarian, 18 of endometrial and 207 cases of cervical cancer were studied. The synthesis of studies with general population as the reference group pointed to a statistically significant positive association between IVF and increased risk for ovarian (RR = 1.50, 95% confidence interval (CI): 1.17-1.92) and endometrial (RR = 2.04, 95% CI: 1.22-3.43), but not cervical (RR = 0.86, 95% CI: 0.49-1.49) cancers. On the contrary, when infertile women were used as the reference group, no significant associations with ovarian, endometrial or cervical cancer types were noted (RR = 1.26, 95% CI: 0.62-2.55 RR = 0.45, 95% CI: 0.18-1.14 and RR = 5.70, 95% CI: 0.28-117.20, respectively). conclusions: IVF does not seem to be associated with elevated cervical cancer risk, nor with ovarian or endometrial cancer when the confounding effect of infertility was neutralized in studies allowing such comparisons. Of note, only one study provided follow-up longer than 10 years for the group exposed to IVF. Future cohort studies should preferably use infertile women as the reference group, rely on IVF-registered valid exposure data, adjust for a variety of meaningful confounders and adopt relatively longer follow-up periods before sound conclusions are drawn. © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

2013

Siristatidis, C.
Sergentanis, T.N.
Kanavidis, P.
Trivella, M.
Sotiraki, M.
Mavromatis, I.
Psaltopoulou, T.
Skalkidou, A.
Petridou, E.T.

Human Reproduction Update

19

2

105-123

clomifene citrate; follitropin; gonadorelin derivative; gonadotropin derivative; human menopausal gonadotropin, cancer risk; cancer screening; cohort analysis; controlled ovary hyperstimulation; data synthesis; endometrium cancer; female infertility; fertilization in vitro; follow up; gonadotropin secreting cell; human; infertility therapy; information processing; meta analysis; multiple cycle treatment; ovary cancer; population; priority journal; quality control; review; risk factor; systematic review; uterine cervix cancer; uterus cancer, Cohort Studies; Endometrial Neoplasms; Female; Fertilization in Vitro; Humans; Infertility, Female; Ovulation Induction; Pregnancy; Risk; Uterine Cervical Neoplasms

https://doi.org/10.1093/humupd/dms051

10.1093/humupd/dms051

https://pergamos.lib.uoa.gr/uoa/dl/object/3128103