Title:
Cord blood nesfatin-1 in large for gestational age pregnancies
Languages of Item:
English
Abstract:
Objective: To investigate possible alterations in cord blood levels of
adipokine nesfatin-1 (secreted by adipose tissue and pancreatic
beta-cells and implicated in glucose metabolism and insulin resistance),
as well as insulin, in large (LGA) and appropriate for gestational age
(AGA) pregnancies, granted that these groups differ in body fat mass and
metabolic/endocrine mechanisms.
Materials and methods: Cord blood nesfatin-1 and insulin concentrations
were prospectively measured in 40 LGA (9 born from diabetic and 31 from
non-diabetic mothers) and 20 AGA singleton full-term infants as well as
their mothers.
Results: Cord blood nesfatin-1 concentrations were significantly lower
in LGA compared to AGA neonates (b = -0.206, SE 0.07, p = 0.005).
However, cord blood nesfatin-1 concentrations were elevated in infants
born from mothers with gestational diabetes mellitus (GDM), compared to
those born from non-diabetic mothers, after controlling for group (b =
0.190, SE 0.10, p = 0.05). Finally, cord blood nesfatin-1 concentrations
were lower in cases of vaginal delivery (b = 0.11, SE 0.05, p = 0.042).
Insulin levels were significantly elevated, as customized centiles
increased (b = 0.004, SE = 0.002, p = 0.016). No significant correlation
was found between insulin and nesfatin-1 in maternal and umbilical cord
levels.
Conclusions: In this study nesfatin-1 levels are decreased in LGA
compared to AGA fetuses. Fetal nesfatin-1 concentrations are higher in
cases of GDM and cord blood nesfatin-1 concentrations are lower in cases
of vaginal delivery. (c) 2012 Elsevier Ltd. All rights reserved.
Authors:
Boutsikou, Theodora
Briana, Despina D.
Boutsikou, Maria and
Kafalidis, George
Piatopoulou, Despoina
Baka, Stavroula and
Hassiakos, Demetrios
Gourgiotis, Demetrios
Malamitsi-Puchner,
Ariadne
Publisher:
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Keywords:
Adipokines; Fetus; Insulin resistance; Neonate; Nesfatin-1
Official URL (Publisher):
DOI:
10.1016/j.cyto.2012.10.029
