Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Kalampogias Aimilios
Dissertation committee:
Βασιλική Γεννηματά, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημήτρης Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Σιάσος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Τσιούφης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Φιλιππάτος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντινία Αγγέλη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Γκατζούλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη των επιπέδων των μετα - μεταγραφικών παραγόντων σε πάσχοντες απο καρδιακή ανεπάρκεια και μελέτη της διακύμανσης των επιπέδων τους με τα νατριουρητικά πεπτίδια σε νοσηλευόμενους με οξεία απορρύθμιση καρδιακής ανεπάρκειας
Translated title:
Study of the levels of post-transcription factors in patients with heart failure and study of the differentiation of their levels with natriuretic peptides in patients with acute deregulated heart failure
Summary:
MicroRNAs (miRNAs) are twenty-three nucleotide single-stranded non-coding RNAs that regulate gene expression at the posttranscriptional level. They negatively or positively regulate gene expression by binding to messenger RNA (mRNA) and inhibiting protein production in the resulting complementary strand, driving expression level changes in response to various stimuli. Recent studies have shown that miRNA levels can be measured in serum and plasma samples from patients with HF, but their use as a biomarker for HF is limited due to the variability of levels between different individuals mainly caused by a number of confounding factors, such as the timing of sample collection. MicroRNAs can modulate cardiac gene expression at the transcriptional, translational, and post-translational levels. A key finding is that some of these post-transcriptional mechanisms appear to be independent of their target mRNA transcripts. Furthermore, other findings indicate that dysregulation of specific miRNA clusters may represent a biomarker for heart failure diagnosis and treatment response. Biomarkers like BNP and microRNAs are key indicators for assessing severity of heart failure; they're especially important for patients with left ventricular dysfunction (LVF). BNP is released in the body when the heart is under stress, and shows up in blood samples. If a person has reached the stage of acute heart failure, BNP levels will rise (10 times) from the start of his condition. The characterisation of molecular pattern expression of microRNAs in the circulatory system of HF patients will be a milestone in a better understanding of the pathology underlying the causes.
Main subject category:
Health Sciences
Keywords:
Brain natriuretic peptide, MicroRNAs, Heart failure, Acute heart failure, Chronic heart failure, Ejection fraction, Messenger RNA, Biomarkers
Number of references:
625
File:
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KALAMPOGIAS_diatrivi.pdf
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File access is restricted only to the intranet of UoA.
