Unit:
Κατεύθυνση Νεοπλασματική Νόσος στον Άνθρωπο: Έρευνα και Κλινικοπαθολογοανατομική Προσέγγιση στα Πλαίσια της Εξατομικευμένης Ιατρικής (Διάγνωση και Στοχευμένη Θεραπεία)Library of the School of Health Sciences
Author:
Alexandris Dimitrios
Supervisors info:
Γακιοπούλου Χαρίκλεια, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Νόννη Αφροδίτη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Θεοχάρης Σταμάτιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η τοξικότητα των νεότερων ανοσοθεραπευτικών μορίων στο δέρμα και το νεφρό. Παθολογοανατομική και κλινική έκφραση
Translated title:
Cutaneous and renal toxicity associated with new immunotherapeutic checkpoint-ihnibitors. Pathological and clinical expression review and a case series presentantion
Summary:
Introduction
Recent advances in cancer immunotherapy have incorporated immune check point inhibitors (ICIs) in several
therapeutic algorithms of various cancers. Hence, these medical agents have been associated with several
adverse events from all body systems, particularly skin and renal.
Methodology
This paper reviews the existing literature regarding renal and skin toxicity from ICIs in cancer patients. A
retrospective study of cancer patients in Greece, who presented with ICI- related renal and cutaneous adverse
recorded events at Oncology Department of Evaggelismos General Hospital, in a mean time of 2 subsequent
years, is also provided.
Results
Eleven patients with renal toxicity post ICIs treatment were included in our study and seven patients with cutaneous
ICI- related adverse reactions . All demographic, clinical and histological data are presented and discussed.
Conclusion
This study describes in details, the characteristics of ICI- related renal and cutaneous toxicity. It provides
evidence about promptly detection of clinical features in skin and renal in association with ICI- related toxicities
and fully explains these special distinct histological patterns.
Main subject category:
Health Sciences
Keywords:
Immunotherapy, Adverse Events, Skin, Kidney, Immune-related Adverse Events, Toxicity
Number of references:
154
File:
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ΑΛΕΞΑΝΔΡΗΣ.pdf
6 MB
File access is restricted only to the intranet of UoA.
