Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Michalopoulou Fani
Dissertation committee:
Κοτσιφάκη Ελένη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κουτσιλιέρης Μιχάλης, Καθηγητής, Ιατρική Σχολή, ΕKΠΑ
Λυμπέρη Μαρία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αγγελογιάννη Παναγούλα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαυραγάνη Κλειώ, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Φιλίππου Αναστάσιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χατζηγεωργίου Αντώνης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Έκφραση των ισομορφών του IGF-1 στο καρκίνωμα του νεφρού
Translated title:
Expression of IGF-1 isoforms in renal cell carcinoma
Summary:
Background / Aim: Insulin-like growth factor-1 (IGF-1) regulates various aspects of cancer biology. There is a growing body of evidence regarding the
potential distinct role of IGF-1 isoforms, particularly of IGF-1Ec, in the pathophysiology of various human cancer types, however, there are no studies
which examined the expression of the different IGF-1 isoforms in renal cell
carcinoma (RCC). This study aimed to characterize the expression of IGF1Ec in human RCC tissues and investigated whether its expression is associated with the histopathological type of RCC as well as with the overall survival of patients.
Materials and Methods: Formalin-fixed paraffin-embedded renal tissue
samples from 94 patients (58 males and 36 females) were assessed for
IGF-1Ec expression by immunohistochemistry.
Results: RCC tissues showed mainly cytoplasmic IGF-1Ec staining but immunoreactivity of IGF-1Ec was also localized in the cell membrane. Significantly lower IGF-1Ec expression was found in clear-cell RCC vs. all other
histological types (p=0.010), and this remained significant after adjusting for
tumor size, grade, stage, and mitotic index (p<0.05). No association was
found between IGF-1Ec expression level and overall survival of patients with
RCC.
Conclusion: The differential expression of IGF-1Ec isoform among the RCC
histopathological types may indicate its histological type - specific regulation
and possibly suggests a discrete biological role of this isoform in the pathophysiology of RCC.
Main subject category:
Health Sciences
Keywords:
Insulin-like growth factor-1, Isoform insulin growth factor 1Ec, Insulin growth factor 1 receptor, Renal cell carcinoma, Clear cell renal cell carcinoma
Number of references:
123
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