Supervisors info:
Σπυρίδων Ζακυνθινος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεωργία Τρακαδά, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Εμμανουήλ Βαγιάκης, Πνευμονολόγος-Εντατικολόγος, PHD, Διευθυντής Ε.Σ.Υ.,Υπ. Εργ. Ύπνου Νοσοκομείου ΕΥΑΓΓΕΛΙΣΜΟΣ, Πιστοποιημένος Ιατρός Ύπνου από Υπ. Υγείας
Summary:
Background-Aim of the Study: Sleep is an essential function and plays a vital role, for a person's health and wellbeing. The COVID-19 pandemic brought important implications on daily life and sleep quality. There are several studies that point out the high prevalence of sleep disruption and psychological disorders in patients with COVID-19 infection. However, little is known about sleep after the recovery of COVID-19 infection. The aim of this study was to investigate sleep quality in patients, one month after hospital admission for COVID-19 infection. possible associations between regular sleep disruption and immunity response after vaccination for COVID-19.
Methods: This is an observational study (a case-control study). Eighty-seven patients suffering from moderate or severe infection of COVID-19 and needed an admission at the hospital were enrolled in this study. Patients had a follow-up examination one month after their discharge from the hospital, and they were asked to complete questionnaires for depression, stress, physical and mental health status, and sleep quality. Eighty-seven healthcare workers, with no previous history of COVID-19 infection were enrolled as a control group.
Results: Sleep quality was associated with sleep latency (r=0.629, p=0.0001), with total health status, (r=-0.448, p=0.0001), with physical status (r=-0.373, p=0.0001), and with mental status (r=-0.456, p=0.0001). Sleep quality was also associated with stress (r=0.344, p=0.001), and depression (r=0.266, p=0.013). Sleep quality was associated and with biochemical factors, such as hematocrit (r=-0.314, p=0.030), hemoglobin (r=-0.373, p=0.009), platelets count (r=0.341, p=0.034) and levels of C-reactive protein (CRP) (r=-0.685, p=0.042). After multivariate analysis, the relationship between sleep quality and health status remained, after adjusting for confounders factors. Sleep quality did not differ between the two groups (p=0.129). There were no differences between the two groups in sleep latency, which is an indicator of insomnia (p=0.281).
Conclusions: Our observations did not demonstrate sleep quality differences between the group of COVID-19 sufferers and the control group. This conclusion is limited by the fact that healthcare professionals, that were used as a control group, often experience a chronic circadian disruption, and they have increased prevalence of stress and depression, compared to general population.
Keywords:
Sleep quality, Covid19, Depression, Stress, Health quality
