Unit:
Κατεύθυνση Σακχαρώδης Διαβήτης και ΠαχυσαρκίαLibrary of the School of Health Sciences
Supervisors info:
Νικόλαος Τεντολούρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Μακρυλάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αλέξανδρος Κόκκινος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος των AGES στην επούλωση των διαβητικών ελκών
Translated title:
The role of AGES in the healing of diabetic wounds
Summary:
Diabetes Mellitus is a chronic disease which has reached pandemic proportions, during the last years. Among its most serious complications is the diminished wound healing, which is mainly attributed to hyperglycemia and other related to it factors. According to the scientific literature, Advanced Glycation End-Products (AGEs) are involved in the mechanisms of the wound healing suppression process. The scope of the present thesis is to shed light on the role that AGEs play in diabetic wounds healing, as well as recording relevant studies’ outcomes. After a systematic literature review, several interesting conclusions were deduced concerning not only the ways in which AGEs suppress the wound healing process but also the mechanisms they are involved in. Regarding the studies included, most of them are tested on animal models or on models of reduced healing, which cannot mimic the corresponding conditions in humans. Therefore, in vivo studies on humans would be worth conducting. Lastly, informing people suffering from Diabetes Mellitus, as well as their relatives, on the appropriate nutrition patterns aiming at the prevention consists in a necessity.
Main subject category:
Health Sciences
Keywords:
Advanced Glycation End-Products, Diabetes Mellitus, Diabetic ucler, Nutrition, Wound healing
