Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Supervisors info:
Μαυρογιάννη Δέσποινα , ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταύρος Σοφοκλής, Ακαδημαϊκός Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Παράμετροι οξειδωτικού στρες και γυναικεία γονιμότητα: Ο ρόλος των προϊόντων τελικής γλυκοζυλίωσης ( Advanced glycation end products - AGES)
Translated title:
Parameters of oxidative stress and female fertility: The role of advanced glycation end products (AGES)
Summary:
Oxidative stress is the consequence of oxygen in aerobic respiration in living organisms and is a state of imbalance between the production of reactive oxygen species (ROS) and the ability of endogenous antioxidant mechanisms to neutralize them. The concentration of ROS under conditions of oxidative stress induces the generation of advanced glycation end products (AGES) which, together with exogenously ingested AGES (mainly through processed food and tobacco), can be used to reduce the oxidative stress of the body, exert regulatory effects on cell signalling pathways associated with the pathophysiology of chronic diseases (e.g. diabetes, atherosclerosis, nephro-degenerative diseases) and physiological functions such as reproduction.
In the present literature review is discussed the role of AGES and their receptor (receptor of advanced glycation end products - RAGE) in conditions related to female fertility (ovarian function, endometriosis, polycystic ovary syndrome, abnormal placentation, intrauterine growth retardation, pre-eclampsia, late miscarriages). It is also examined the importance of AGES as a future therapeutic target in the treatment of female infertility.
Main subject category:
Health Sciences
Keywords:
Female fertility, Advanced Glycation End Products
Number of references:
136
