Unit:
Speciality Fetal Maternal MedicineLibrary of the School of Health Sciences
Author:
Badagionis Miltiadis
Supervisors info:
Μακάριος Ελευθεριάδης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτα Περβανίδου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Θεόδωρος Σεργεντάνης, Ακαδημαϊκός Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Early or late onset preeclampsia and neurodevelopment in the offspring: a systematic review and meta-analysis
Translated title:
Early or late onset preeclampsia and neurodevelopment in the offspring: a systematic review and meta-analysis
Summary:
The aim of this systematic review and meta-analysis is to examine the association between exposure to preeclampsia during pregnancy and the occurrence of cerebral palsy in offspring. For this reason, the authors searched PubMed/Medline, EMBASE, and Google Scholar databases (end-of- search: 22 November 2021) and identified the most relevant studies. Then, a meta-analysis of all the eligible studies was performed. Subgroup and meta-regression analyses by study design, degree of adjustment, and geographical region were also conducted. A total of 10 studies were finally included, and no statistical significance was noted in the association between preeclampsia and cerebral palsy (pooled OR = 1.16, 95% CI: 0.77–1.74). The subgroup of studies that provided adjusted odds ratios for any variable except for gestational age showed a statistically significant association (pooled OR = 1.62, 95% CI: 1.36–1.93), whereas the association dissipated in studies also adjusting for gestational age (pooled OR = 1.63, 95% CI: 0.48–5.50). In conclusion, it seems that preeclampsia is not associated with cerebral palsy independently of gestational age; however, further research is needed to shed light on this topic.
Main subject category:
Health Sciences
Keywords:
Preeclampsia, Cerebral palsy, Offspring, Prematurity, Gestational age
Number of references:
157
