Κατεύθυνση Βασική Έρευνα
Library of the School of Health Sciences

2022-11-16

2022

Katourtsidi Zoi

Μαρία Κ. Αγγελοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Γεώργιος ΒαΪόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μιχαήλ Κουτσιλιέρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Κυτταρομεγαλοϊός και μεταμόσχευση αρχέγονων αιμοποιητικών κυττάρων

Greek

Cytomegalovirus and hematopoietic stem cell transplantation

Cytomegalovirus(CMV) infection after hematopoietic stem cell transplantation (HSCT)is one of the critical complications associated with immune recovery.The spectrum of CMV infection is quite extensive:from asymptomatic CMV reactivation mainly appearing as CMV viremia to fatal CMV infection of the gut ,the liver, the lungs, or even the brain.In addition to organ involvement, CMV reactivation can cause immunosuppression or graft failure that can lead to the development of further complications.Currently,preventive therapy ,based on the monitoring of CMV in blood by PCR (polymerase chain reaction), is a key factor in reducing CMV morbidity.In the last decades,new antiviral drugs and clinical trials for prophylaxis in high risk groups have been introduced.In addition ,data on immunological monitoring and immunotherapy have been collected.In this thesis ,which is structured in six chapters,we will review the current state of research and the latest updates in this field ,while considering future perspectives such as immunotherapy in HSCT patients.

Health Sciences

Cytomegalovirus, Hematopoietic stem cell transplantation, Host immune response mechanism, T-cell therapeutic regimens

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https://pergamos.lib.uoa.gr/uoa/dl/object/3237759