Unit:
Κατεύθυνση Χειρουργική ΟγκολογίαLibrary of the School of Health Sciences
Author:
Gialelis Nikolaos
Supervisors info:
Δημήτριος Θεοδώρου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Ζωγράφος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Πρωτοπαθής καρκίνος ωοθηκών: πρωτογενής κυτταρομείωση έναντι εισαγωγικής χημειοθεραπείας και ενδιάμεσης κυτταρομείωσης
Translated title:
Primary ovarian cancer: primary debulking surgery versus neoadjuvant chemotherapy and interval debulking surgery
Summary:
In the present work, the position of neoadjuvant chemotherapy in the initial treatment of advanced-stage primary ovarian cancer in women is reviewed in the literature. First, the prerequisite current data on the specific malignant entity of the human gynecological reproductive system are presented, which concern the histological classification and staging, epidemiology and genetics, diagnosis and treatment. Next, the central question of the present work is posed, namely the possible superiority of the treatment strategy of interval debulking surgery after neoadjuvant chemotherapy (possibly followed by adjuvant chemotherapy in a third step), over the corresponding established one of primary debulking surgery followed by adjuvant chemotherapy, regarding the survival, the perioperative complications and the quality of life. A review, of studies comparing these two treatment strategies at first diagnosis, follows. Finally, criteria are presented, based on which patients are selected for treatment with the appropriate therapeutic plan.
Main subject category:
Health Sciences
Keywords:
Ovarian cancer, Advanced stage, Neoadjuvant chemotherapy, Primary debulking surgery, Interval debulking surgery, Adjuvant chemotherapy, Treatment strategy, Survival, Perioperative complication, Quality of life, Patient selection, Triage algorithm
Number of references:
218
