Unit:
Κατεύθυνση Ογκολογία Θώρακα: Σύγχρονη Κλινικο-Εργαστηριακή Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Author:
Papavasileiou Aikaterini
Supervisors info:
Δημήτριος Στραβοπόδης, Αναπληρωτής Καθηγητής, Τμήμα Βιολογίας, ΕΚΠΑ
Βασίλειος Ραμφίδης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Ηλίας Κοττέας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μικροδορυφορική γενετική αστάθεια και αντιμετώπιση συμπαγών όγκων με τη βοήθεια νανοσωματιδίων αντιγόνων
Translated title:
Microsatellite genetic instability and antigen nanoparticle-assisted treatment of solid tumors
Summary:
Microsatellites are found in several cancers, the most common being colorectal cancer and stomach cancer. Microsatellites are duplicate strands of DNA in the genome that are created due to non-correction of mismatches during replication. Tumor characterization based on microsatellite genetic instability is important for the prognosis of patients, for the evaluation of malignancy, and for the response of patients to immunotherapy and chemotherapy. Studies have been performed in MSI patients receiving immunotherapy and chemotherapy, and the results of these studies suggest that 5-FU chemotherapy could be a treatment option in stage III MSI-H CRC patients. The benefit of oxaliplatin-based adjuvant chemotherapy is increased in patients with stage II to III colon cancer. A new therapeutic strategy that is still in the experimental stage is the use of antigen nanoparticles. Nanoparticles due to their properties and characteristics are considered ideal nanotransmitters of drugs, proteins and nucleotides. The advantage of using nanoparticles is that they do not cause inflammation, are non-toxic and accumulate in tumors. At present the antigen nanoparticles have been used in melanoma mice in which the tumor is irradiated, then nanoparticles are administered which bind the tumor antigens. The results of these studies showed that in mice treated with PLGA and Mal AC-NPs nanoparticles, the tumor dimension had the smallest increase with time after vaccination compared to all groups. It was also observed that in secondary tumors
administration of only RT and RT in combination with aPD-1 had no benefit. This method is very promising although it is still in experimental stages
Main subject category:
Health Sciences
Keywords:
MSI, Antigen nanoparticles, Tumor microenvironment, Immunotherapy
Number of references:
145
