Faculty of Medicine
Library of the School of Health Sciences

2023-03-03

2023

Karampetsou Nikoleta

Παύλος Πατάπης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Περρέα, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Κόντζογλου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Δημητρούλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Ηλιόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Βερύκοκος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Στυλιανός Κύκαλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Μελέτη της αθηροσκληρυντικής καρδιοπάθειας σε σχέση με τη διάδραση του επικαρδιακού λίπους

Greek

Investigation of the role of epicardial adipose tissue in coronary atherosclerosis procedure

Introduction: Epicardial adipose tissue is a visceral fat unit which plays
a determining and significant role in several cardiovascular diseases, such as
coronary artery disease.
Aim: In this clinical study we sought to gather information regarding
local inflammation differences among epicardial adipose tissue biopsies,
whereas we also investigated the clinical importance of epicardial adipose
tissue thickness measurement,
Methods: Thirty two patients who suffered from advanced coronary
artery disease and underwent coronary artery bypass graft surgery (CABG)
were included in the study. Epicardial adipose tissue samples were
gathered from the region of left anterior descending artery with and without
stenosis.
Results: The mean age of the enrolled patients was 64±1.1 years,
whereas the mean epicardial adipose tissue thickness was 7.4± 1.9 mm.
Totally eleven inflammatory factors were studied regarding their epicardial
adipose tissue concentrations. Seven inflammatory factors presented
statistically significant differences between biopsies from the stenotic and
non-stenotic regions. Both tumor necrosis factor-α (TNF-α) and
interleukin- 1 α (Il- 1 α) were significantly correlated with clinical
morbidities, such as diabetes.
Conclusions: Pericoronary epicardial adipose tissue seems to be a a
source of local inflammatory mediators which contribute in local
inflammation procedure in patients with advanced coronary artery disease.

Health Sciences

Atherosclerosis, Coronary artery disease, Epicardial adipose tissue, Inflammation

No

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/3284880