Supervisors info:
Τζέτη Μαρία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μητράκος Αναστάσιος, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Πούλου Μυρτώ, Επιστημονική Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Nowadays, with the discovery of new techniques for studying the human genome, it is possible to
diagnose and, in some cases, even treat genetic diseases, among which breast cancer has a special
importance, a disease with a high rate of mortality and morbidity. The object of this study is to support
and enhance the role of pets, dog (Canis Lupus Familiaris) and cat (Felis Catus) as natural study models
that are increasingly involved in research projects worldwide in this direction.
Information is extracted from the relevant literature and articles. In particular, there is the possibility
of open electronic access to platforms that record the results of research programs, as well as
information websites held by international organizations and universities dealing with genetic diseases
and breast cancer. The comparative study of genomic lesions and molecular pathways leading to the
genesis and progression of the above diseases, the response to experimental trial treatment regimens
and the study of factors that affect the response to treatment, document the usefulness of studying
the same disease process in animals such as dogs and cats.
Based on the above, the particular architecture of their genome, and the homology it presents with
humans, facilitates the study of genetic diseases (Stephen J. et al.2002). Also, the study of the
phenotypic manifestations of diseases in populations of families of animals with genetic uniformity led
to the discovery of candidate genetic sites responsible for the disease mutations (Van Steenbeek FG
et.al.2016).
Common living and feeding conditions between humans and pets broaden the scope of study by
including the environmental factor, allowing for a holistic approach to the diagnosis, prevention, and
treatment stage. In addition, studies on the safety and efficacy of authorized medicinal products, given
to dogs and cats, have resulted in a more rapid approval. (Shearin AL et.al.2010).
The study of domestic animals naturally affected by genetic disease is fully in line with the societal
demand for the discovery of prognostic markers, resulting in comprehensive testing, appropriate
preventive measures to reduce the likelihood of future disease and finally the appropriate treatment
regimen. In order to achieve the above objective, research is carried out without compromising their
well-being, while veterinary patients benefit by increasing their chance of survival and improving their
quality of life.
