Κατεύθυνση Αναπνευστική Ανεπάρκεια και Μηχανικός Αερισμός
Library of the School of Health Sciences

2023-03-15

2023

Bakakos Agamemnon

Νικολέττα Ροβίνα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αντωνία Κουτσούκου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γρηγόριος Στρατάκος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

SARS-COV-2 σε υπερήλικες ασθενείς: Πέρα από τη λοίμωξη

Greek

SARS-COV-2 in elderly population: Beyond the infection

Objective: The impact of severe infection from COVID-19 and therefore the need for life support in an ICU environment is a fact that caused immense pressure in healthcare systems around the globe. Accordingly, elderly people faced multiple challenges and sometimes were unable to secure a bed in an ICU. On this basis, we decided to perform this study, to assess the impact of age on COVID-19 mortality n critically ill patients.
Materials and Methods: In this retrospective study, we collected data from 300 patients who were hospitalized in the ICU of a general Greek Hospital. We split patients into two age groups, with a threshold of 65 years old. The primary objective of this study was the survival of patients in a follow up period of 60 days from their admission to the ICU. Secondary objectives were to determine whether mortality is affected from other factors, such as sepsis and clinical and laboratory factors, like Charlson Comorbidity Index (CCI), APACHE II and d-dimers, CRP etc.
Results: The survival of all patients in the ICU was 75.7%. Those in the age group <65 years old expressed a survival rate of 89.3%, whereas those in the age group >=65 years old had a survival rate of 58% (p-value <0.001). In the multivariate Cox regression, the presence of sepsis and the increased CCI were revealed to be independent predictors of mortality in 60 days (p-value <0.001), while the age group did not maintain its statistical significance (p-value=0.320).
Conclusions: Age alone as a simple number is not capable of predicting mortality in patients with severe infection from COVID-19 in the ICU. We need to use more composite clinical markers which may better reflect the biological age of patients, like CCI. Moreover, the effective control of infections in the ICU is of utmost importance for the survival of patients, since avoiding septic complications can drastically improve the prognosis of all patients, no matter their age.

Health Sciences

Covid-19, SARS-COV-2, ICU, Respiratory failure, Elderly

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https://pergamos.lib.uoa.gr/uoa/dl/object/3301063