Faculty of Medicine
Library of the School of Health Sciences

2023-06-02

2023

Petrou Eleni

Τσαντές Ε. Αργύριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κοκόρη Στυλιανή, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γιαλεράκη Αργυρή, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κριεμπάρδης Αναστάσιος, Αναπληρωτής Καθηγητής, Τμήμα Βιοιατρικών Επιστημών, ΠΑΔΑ
Βαλσάμη Σερένα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βρυώνη Γεωργία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Τσιριγώτης Παναγιώτης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

In vitro μελέτη της αιμοστατικής λειτουργίας των επεξεργασμένων με ριβοφλαβίνη αιμοπεταλίων αφαίρεσης

Greek

In vitro μελέτη της αιμοστατικής λειτουργίας των επεξεργασμένων με ριβοφλαβίνη αιμοπεταλίων αφαίρεσης

Reducing the risk of pathogen transmission to transfusion recipients is one of the great concerns in transfusion medicine. Important among the measures suggested to minimize pathogen transmission is pathogen reduction technology (PRT) systems. The Mirasol PRT System for platelets and plasma uses riboflavin and UV light to inhibit both pathogen and white blood cell replication. Pathogen inactivation may accelerate or induce lesions, potentially accounting for reduced viability. The PRT-treated platelets show signs of increased cellular activation, increased metabolism and reduced hemostatic capacity. The purpose of the study was to investigate the effect of PRT on the hemostatic capacity of platelets. Untreated platelets and PRT-treated platelets derived from ten apheresis platelet concentrates (PCs). PCs were divided into equally leading to twenty platelet concentrates that were stored in plasma. All PCs, were evaluated in vitro on days 1, 3, and 5 after collection, for metabolic properties, hemostatic properties, functionality and procoagulant activity. We observed that PRT adversely affected the metabolic and hemostatic profile of platelets in a time-dependent manner. PRT-treated platelets also showed increased activation and procoagulant activity particularly at the end of storage. Thus, PRT led to exhaustion of the hemostatic process especially at the end of the storage time. Well-designed clinical studies are needed to determine whether this in vitro reduced platelet functionality after PRT is reflected in vivo.

Health Sciences

Pathogen reduction technologies, Platelets, Thromboelastometry

No

0

Yes

76

149

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/3328505