Unit:
Κατεύθυνση Απομόνωση, Ανάπτυξη, Παραγωγή και Έλεγχος Βιοδραστικών Φυσικών ΠροϊόντωνLibrary of the School of Science
Supervisors info:
Ευσταθία Ιωάννου Αναπλ. Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ,
Βασίλειος Ρούσσης, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ,
Όλγα Τζάκου, Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Original Title:
Απομόνωση και ταυτοποίηση δευτερογενών μεταβολιτών από μαλακό κοράλλι του γένους Nephthea
Translated title:
Isolation and structure elucidation of secondary metabolites from a soft coral of the genus Nephthea
Summary:
The marine biosphere is the largest on earth and hosts a huge number of diverse organisms. Due to the different living conditions in comparison to those in the terrestrial environment, the
production of specific secondary metabolites is an important adaptation mechanism of marine organisms in order to survive. Many of these metabolites possess biological properties that make them significant as potential drugs. Soft corals belonging to the genus Nephthea (family Nephtiidae) produce a large number of bioactive compounds, many of which have anticancer properties. In the framework of the present thesis, the chemical composition of the organic extract of a soft coral of the genus Nephthea was studied, specimens of which were collected from the region Yanbu in the Saudi Arabian Red Sea, at the depth of 6-8 m, in November of 2018. After exhaustive extraction of the soft coral specimens with organic solvents, the extract was subjected to a series of chromatographic separations that led to the isolation of thirteen metabolites, among which eight have been identified so far on the basis of their NMR and MS spectroscopic data and comparison with literature data. Specifically, the identified metabolites include five sesquiterpenes and three diterpenes.
Main subject category:
Science
Keywords:
Isolation; structure elucidation; natural products; Nephthea; soft coral
