Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Kazantzis Dimitrios
Dissertation committee:
Ειρήνη Χατζηράλλη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτης Θεοδοσιάδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Κρούπης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λαμπαδιάρη Βάϊα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μουτσάτσου-Λαδίκου Παρασκευή, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βρυώνη Γεωργία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σεργεντάνης Θεόδωρος, Επίκουρος Καθηγητής, Τμήμα Πολιτικών Δημόσιας Υγείας, ΠΑΔΑ
Original Title:
Επιδημιολογική μελέτη κλινικών και βιοχημικών παραγόντων κινδύνου σε ασθενείς με απόφραξη φλέβας αμφιβληστροειδούς
Translated title:
Clinical and biochemical risk factors in patients with retinal vein occlusion
Summary:
Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of sight loss due to its complications. It is divided into central retinal vein occlusion and branch retinal vein occlusion depending on the site of the occlusion. RVO is a multifactorial disease and several risk factors for RVO have been identified, such as hypertension, diabetes and hyperlipidemia. In the present study participants were 106 patients diagnosed with RVO who underwent ocular and laboratory investigations. We aimed to identify demographic, clinical and laboratory risk factors for RVO. Hypertension, homocysteine and neutrophil to lymphocyte ratio (NLR) were identified as risk factors for CRVO, while homocysteine and elevated triglycerides were identified as risk factors for BRVO in multivariable analysis.
Furthermore, 65 patients had extensive imaging with optical coherence tomography and fluorescein angiography and we tried to identify any correlations between imaging characteristics and laboratory findings. Patients with subretinal fluid had increased NLR, while patients with hyperreflective foci and retinal cysts had increased triglycerides. In addition, patients with increased central subfield thickness had increased lymphocytes and urea levels.
53 patients with macular edema secondary to RVO were treated with anti-VEGF agents and were followed for 12 months. We aim to evaluate if any of the laboratory and imaging characteristics could predict “favorable” response at the end of the follow up. Increased monocytes to lymphocytes ratio (MLR), the absence of ellipsoid zone and external limiting membrane disruption, the absence of hyperreflective foci and the absence of macular ischemia were prognostic factors of “favorable” response.
Main subject category:
Health Sciences
Keywords:
Ophthalmology, Retina, Retinal vein occlusion, Optical coherence tomography, Risk factors
Number of references:
159
File:
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Kazantzis_Dimitrios_PhD.pdf
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