Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Χαράλαμπος Δεληβελιώτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Αλαμανής, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Σκολαρίκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Στραβοδήμος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Βαρκαράκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Παπατσώρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ηρακλής Μητσογιάννης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση των ανθρωπομετρικών χαρακτηριστικών στην εμφάνιση του καρκίνου της ουροδόχου κύστεως: μία μελέτη ασθενών-μαρτύρων
Translated title:
The effect of anthropometric characteristics in the occurrence of urinary bladder cancer: a case-control study
Summary:
Background: Risk factors like smoking, radiation, chronic infections and exposure to occupational chemicals are strongly associated with occurrence of bladder cancer. Association between increased body weight and bladder cancer has been controversial. The aim of this case-control study is to evaluate association of anthropometric characteristics on bladder cancer incidence in Greek population.
Methods: This case-control study was conducted at a tertiary hospital in Greece with cases being patients with bladder cancer diagnosed within the last 2 years and controls patients admitted to hospital for reason other than cancer and not related to common risk factors related to bladder cancer. Anthropometric characteristics like weight, height, body mass index, waist and hip circumference were measured. Analyses was done with R (Vienna, Austria).
Results: Comparison between groups showed that patients with bladder cancer had higher weight, BMI and waist circumference compared to controls. However, multivariate, binomial logistic regression showed that only age (OR 1.03, 95% CI: 1-1.05, p=0.02), no use of smoke (OR 0.12, 95% CI: 0.07-0.23, p<0.001) and occupation related to bladder cancer (OR 7.45, 95% CI: 2.53-27.93, p<0.001) significantly predicted the incidence of bladder cancer.
Conclusions: Bladder cancer incidence is strongly linked with specific risk factors such as smoking, occupation with exposure to chemicals and smoke, increasing age, radiation and chronic infections. Several studies have shown a weak association between anthropometric characteristics and bladder cancer, although most studies in European populations did not confirm these findings. Similarly in our case-control study in a Greek population, we found potential relationship between increased weight/BMI and waist circumference with bladder cancer, but the association disappeared in multivariate analysis.
Main subject category:
Health Sciences
Keywords:
Carcinoma of urinary bladder, Weight, Height, Anthropometric characteristics, Body mass index
