Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Papachristoforou Eleftheria
Dissertation committee:
Μακρυλάκης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τεντολούρης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κόκκινος Αλέξανδρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λυμπερόπουλος Ευάγγελος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λαμπαδιάρη Βάϊα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ράπτης Αθανάσιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Θανοπούλου Αναστασία, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
H συσχέτιση της υπογλυκαιμίας με δείκτες οξειδωτικού στρες
Translated title:
Association of hypoglycemia with biomarkers of oxidative stress
Summary:
Hypoglycemia has been associated with complications from the vasculature. The contributing effects of oxidative stress (OS) on these actions have not been sufficiently studied, especially in daily, routine clinical practice. We examined the association of hypoglycemia encountered in daily clinical practice with biomarkers of OS and endogenous antioxidant activity in persons with type 1 (T1D) or type 2 (T2D) diabetes who experienced spontaneous hypoglycemia in the outpatient Diabetes Clinics of two major University Hospitals as well as individuals without diabetes, who had fasting or postprandial hypoglycemic episodes. Several biomarkers of OS (MDA, ADMA, ox-LDL, 3-NT, TBARS) and antioxidant capacity (TAC, superoxide scavenging capacity, hydroxyl radical scavenging capacity, reducing power, ABTS) were measured on blood drawn at the time of detection of hypoglycemia and on another day, under euglycemic conditions. In 31 participants (mean age [±SD] 52.2±21.1 years, 45.2% males), 14 (45.2%) with T2D, 12 (38.7%) with T1D, and 5 (16.1%) without diabetes, no difference in any of the examined biomarkers was found, except for levels of TBARS, a biomarker of lipid peroxidation, which showed significantly lower values during hypoglycemia (p=0.005) as compared with euglycemia. Our study suggests that hypoglycemia encountered in daily clinical practice does not affect OS. Given that only TBARS levels were affected, while MDA, another biomarker of lipid peroxidation, was not, this finding needs confirmation in more extensive studies.
Main subject category:
Health Sciences
Keywords:
Hypoglycemia, Oxidative stress
Number of references:
172
