Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Tsirebolos Georgios
Dissertation committee:
Λουκιανός Ραλλίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σπυρίδων Δευτεραίος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Φιλιππάτος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Παρίσης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Ρίζος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Κρούπης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Τούμπουλης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η συσχέτιση των RAGEs με τη στεφανιαία νόσο
Translated title:
Association of RAGEs with coronary artery disease
Summary:
Background and aims: The multi-ligand receptor for advanced glycation end products (RAGE) and its ligands AGEs and S100/calgranulin proteins are important mediators of inflammation and oxidative stress whereas the soluble form of RAGE (sRAGE) by acting as a decoy and the antioxidant PARK7/DJ-1 exert antiatherogenic effects. We examined whether sRAGE and its ligands AGEs, S100A8/A9, S100B, S100A12 and DJ-1 are associated with the presence of angiographic coronary artery disease (CAD) in asymptomatic patients with and without diabetes.
Methods and results: Plasma levels of RAGE ligands, sRAGE and DJ-1 were determined in 50 patients with angiographically proven CAD and in 50 age-matched healthy controls. In the whole cohort, lower levels of sRAGE and higher levels of interleukin-6 (IL-6), the RAGE ligands S100B, S100A12 and the AGEs/sRAGE ratio were associated with CAD. In patients without diabetes (n=72), lower levels of sRAGE and DJ-1 and higher levels of IL-6 and AGEs/sRAGE ratio were associated with CAD. In multivariable analysis, AGEs/sRAGE ratio was an independent predictor of CAD both in the whole cohort (p= 0.034, OR=1.247, [95%CI: 1.024, 1.0519]) and in the subgroup of patients without diabetes (p=0.021, OR=1.363, 95%CI [1.048, 1.771]) on top of established cardiovascular risk factors.
Conclusion: Alterations in plasma RAGE axis inflammatory mediators are associated with atherosclerosis, and higher levels of AGEs/sRAGE ratio are independently associated with CAD in asymptomatic patients and may act as a novel biomarker for predicting CAD. DJ-1 emerges as promising marker of oxidative stress in CAD patients without diabetes, a finding that deserves further study
Main subject category:
Health Sciences
Keywords:
Coronary artery disease, Inflammation, Oxidative stress, AGE/sRAGE, DJ-1
Number of references:
340
