Faculty of Medicine
Library of the School of Health Sciences

2023-07-03

2023

Neri Anna-Aikaterini

Καρατζάς Θεόδωρος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δοντά Ισμήνη, Καθηγήτρια, Ιατρικής Σχολή, ΕΚΠΑ
Καραμανώλης Γεώργιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κουρκουλής Σταύρος, Καθηγητής, Σχολή Εφαρμοσμένων Μαθηματικών και Φυσικών Επιστημών, ΕΜΠ
Μητάκου Σοφία, Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Σκαλτσούνης Αλέξιος- Λέανδρος, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Χρονόπουλος Ευστάθιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Μελέτη της επίδρασης του εκχυλίσματος από το φυτό Ceratonia siliqua (χαρούπι) στην πειραματικά επαγόμενη οστεοπόρωση

Greek

The effect of Ceratonia siliqua (carob) on experimentally-induced osteoporosis.

A plenitude of research data documents the role of estrogen in the regulation of menopausal symptoms. However, because the use of estrogen hormone therapy is associated with severe side effects, women's preferences are turning to phytoestrogens as an additional, safer treatment option for osteoporosis. The action of phytoestrogens is gaining the interest of many researchers. The present study aimed to examine the effect of Ceratonia siliqua (carob) on experimentally induced osteoporosis in a robust animal model of postmenopausal osteoporosis. Thirty 10-month-old female Wistar rats were randomly assigned to three groups of 10 rats each: control group, ovariectomy group (OVX), and ovariectomy plus C. siliqua group (OVX+CS). Body weight and BMD were measured by dual-energy X-ray absorptiometry (DEXA) at the start of the study. Body weight, food, and water consumption were evaluated every 2 weeks. All groups received food without soy and soy by-products. The food given to the OVX+CS group was supplemented with C. siliqua, in a gradually increasing concentration, until the dose of 3 g/kg/day/rat was reached. All rats underwent three DEXA measurements. The first DEXA measurement was performed for all animals at ten months of age and before ovariectomy. The first DEXA measurement and ovariectomy constituted the protocol's time zero (baseline). The next two DEXA measurements were taken three and six months, after the first measurement (time 0, 3 and 6 months). After the third DEXA measurement, rats were euthanized. The results of the present study of C. siliqua indicated that, a) between the groups of ovariectomized rats and ovariectomized rats that received C. siliqua, there was a significant improvement in bone density loss of the proximal tibia and non-significant differences in bone tibia density, b) administration of C. siliqua significantly increased the thickness index compared to the untreated ovariectomy group, for the right femur, although the thickness index remained significantly lower compared to the control group when it was assessed independently of the leg-factor. These results demonstrate a potentially beneficial effect of C. siliqua in the management of postmenopausal osteoporosis, indicating new potential uses as a pharmacological agent with an osteoprotective role by reducing bone loss in menopause. Further studies are required to determine its efficacy as an osteoprotective agent.

Health Sciences

C. siliqua, Carob, Osteoporosis, Bone mineral density

No

0

Yes

671

185

File access is restricted until 2025-01-03.

https://pergamos.lib.uoa.gr/uoa/dl/object/3332613