The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study

Preprint uoadl:3356123 128 Read counter

Unit:
Faculty of Medicine
Title:
The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study
Languages of Item:
English
Abstract:
The role of probiotics supplementation in type 2 diabetes (T2D) treatment is controversial. The present study aimed to assess the effects of a multi-strain probiotic supplement [LactoLevureR (containing Lactobacillus Acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, and Sac-charomyces boulardii)] over 6 months, on glycemic and lipid levels, as well as alterations in the gut microbiome, among individuals with T2D residing in Greece. A total of 91 adults with T2D (mean age [±SD] 65.12±10.92 years, 62.6% males) were randomized to receive the probiotic supplement or a matching placebo capsule, once daily, for 6 months. Blood chemistries and anthropometric pa-rameters were conducted every 3 months and stool samples were collected at baseline and 6 months. Significant reductions in HbA1c, fasting blood glucose and total cholesterol were observed in participants treated with the probiotics supplement (n=46) compared to the controls (n=45), even after adjustment for a greater decrease in adiposity (waist circumference). Although there were no statistically significant differences in the diversity of the gut microbiome (α- and β-diversity), the administration of probiotics did influence several genera, metabolites, and key enzymes associated with diabetes. Overall, the administration of the multi-strain probiotic LactoLevureR over a 6-month period in individuals with T2D was well-tolerated and had a positive impact on metabolic pa-rameters, alongside improvements in indices of adiposity.
Creation year:
2023
Authors:
Eva Zikou
Nikolas Dovrolis
Charilaos Dimosthenopoulos
Maria Gazouli
Konstantinos Makrilakis
Pages:
20
Keywords:
probiotics; diabetes type 2; gut microbiome
Main subject category:
Health Sciences
Project information:
Διδακτορική διατριβή
File: