Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences

2024-06-11

2024

Kavelidou Marianthi

Βαλσαμάκης Γεώργιος, Επίκουρος Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Θεσσαλίας
Σωτηριάδης Αλέξανδρος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Καλανταρίδου Σοφία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Η υποθαλαμική φλεγμονή και οι διαταραχές της όρεξης στο σύνδρομο πολυκυστικών ωοθηκών

Greek

Hypothalamic inflammation's dual impact: unraveling connections to reproductive and appetite centers in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) ranks as the most common endocrine disorder among women of reproductive age worldwide, showing associations with metabolic, reproductive, endocrine and psychiatric disorders. Despite its prevalence, the exact causal mechanisms remain unclear.
The hypothalamus, a key regulator of fundamental physiological functions, plays a central role. Oversees reproductive function, appetite and metabolism. Specifically, the hypothalamus regulates caloric intake in response to peripheral stimuli related to energy reserves. In addition, the kisspeptinergic system controls the secretion of gonadotropin hormones for normal reproductive changes, and the reward system pathway interacts with feeding behaviors.
This review explores the potential simultaneous impact of hypothalamic inflammation on both reproductive and appetite centers in the context of PCOS and appetite disorders. Additionally, it investigates the role of hypothalamic inflammation, influenced by factors like a saturated fat diet or chronic stress, in contributing to pathological eating habits and disorders observed in women with PCOS.

Health Sciences

Polycystic ovary syndrome (PCOS), Hypothalamic inflammation, Reproductive centers, Appetite regulation, Metabolic disorders, Kisspeptinergic system, Reward system pathways, Saturated fatty acid diet, Chronic stress, Eating disorders

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https://pergamos.lib.uoa.gr/uoa/dl/object/3364207