Unit:
Κατεύθυνση Γενική και Εξειδικευμένη Παιδιατρική: Κλινική Πράξη και ΈρευναLibrary of the School of Health Sciences
Author:
Papageorgiou Anastasia
Supervisors info:
Μπακοπούλου Φλώρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χαρμανδάρη Ευαγγελία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χρούσος Γεώργιος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συσχέτιση σταδίων σεξουαλικής ανάπτυξης στα κορίτσια με ανθρωπομετρικές και ορμονολογικές παραμέτρους
Translated title:
Associations of pubertal stages with anthropometric and hormonal parameters in a Greek female sample
Summary:
BACKGROUND: Recent data regarding the timing of the onset of thelarche and menarche in contemporary Greek girls, as well as correlations with anthropometric and hormonal measurements are lacking.
AIM: This study aimed to present recent trends in pubertal timing and to correlate pubertal stages with anthropometric and hormonal parameters of a Greek female sample.
METHODOLOGY: Data were collected retrospectively from medical records of females aged 6-18 years who attended a tertiary Adolescent Medicine Center over a 5-year period (2016-2020).
RESULTS: Data from 298 girls’ medical records were included in the analysis. Median ages at menarche and thelarche were 12 and 9 years respectively, while mean age at pubarche was 8.97 years. The mean interval between pubertal onset and menarche was 1.99 years. Mean body mass index (BMI) at menarche and thelarche was 20.99 kg/m2 and 18.90 kg/m2 respectively. Mean weight at menarche was 49.6kg, whereas the mean height difference between thelarche and menarche was 19.17 cm. Among participants, 6.31% had premature menarche, while 23.96% had premature thelarche. Birth weight was slightly positive correlated with ΒΜΙ at thelarche/pubarche (r =0.334, p<0.01) and moderately positive correlated with gestational age (r=0.572, p<0.001) Interestingly, BMI at thelarche/pubarche and birth weight were not predictive of premature menarche or premature thelarche. Median (interquartile range-IQR) levels around menarche vs. thelarche were higher for insulin-like growth factor-1 [358.00(140.50) vs. 176.00(55.00) ng/ml], follicle stimulation hormone [5.65(3.14) vs. 3.10(4.23) mIU/ml], testosterone [25.50(31.00) vs. 13.00(21.00) ng/dl], dehydroepiandrosterone sulfate [117.00(112.50) vs. 46.40(51.90) μg/dl] and insulin [17.40(15.05) vs. 8.47(4.97) μIU/ml].
CONCLUSIONS: Pubertal timing of the Greek female sample seems to follow the international downward trends of the last decades. Younger age at menarche was not associated with BMI.
Main subject category:
Health Sciences
Keywords:
Puberty, Thelarche, Menarche, Greece, Pubertal stages
Number of references:
122
