Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Balalis Dimitrios
Dissertation committee:
Νικόλαος Αρκαδόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χάϊδω Σπηλιοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Διαμάντω Ψυρρή, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Βλαχοδημητρόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Φλώρα Ζαγουρή, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Μιχαλόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Δανιάς, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διερεύνηση των επιπέδων έκφρασης μορίων σχετιζόμενων με την εμφάνιση και αντιμετώπιση καρκίνου του μαστού με τριπλά αρνητικό φαινότυπο
Translated title:
Exploration of the expression levels of molecules related to the appearance and treatment of breast cancer with a triple negative phenotype
Summary:
AIM: Angiogenesis plays a critical role in the growth and proliferation of cancer cells. In breast cancer it is mediated by the vascular endothelial growth factor (VEGF) signalling axis. Furthermore, it is regulated by different proangiogenic factors, such as heparin- binding – EGF- like growth factor (HB-EGF) and platelet – derived growth factor – CC (PDGF-CC) in addition to co – receptors, such as neuropilin – 1 (NRP-1), which are implicated in the prognosis and therapy of breast cancer patients. The purpose of the present study is to determine the expression of the aforementioned angiogenic factors in the systemic circulation of women with early breast cancer and the correlation with body mass index (BMI), menopausal status, histological types and molecular subtypes of breast cancer.
PATIENTS AND METHOD: The study cohort consisted of 205 premenopausal and postmenopausal patients with early breast cancer and 31 healthy donors. We assessed the serum levels of VEGF, HB-EGF, PDGF -CC and NRP-1 and investigated the potential associations with clinical and histopathological parameters.
RESULTS: VEGF serum levels were significantly higher in patients with invasive carcinoma in comparison to patients with ductal carcinoma in situ. PDGF-CC serum levels were significantly higher in patients with molecular subtype of LumB (Her2-) in comparison to patients with triple negative molecular subtype. Moreover, we observed a different expression of most biomarkers between overweight/obese and normal weight patients among the breast cancer molecular subtypes. Specifically, overweight/obese patients with triple negative breast cancer exhibited significantly higher HB-EGF serum levels in comparison to normal weight patients.
CONCLUSION: The serum levels of angiogenic factors are associated with molecular subtypes of breast cancer. Moreover, some of these angiogenic factors are affected by the histological type, the ΒΜΙ and the menopausal status of patients with breast cancer. The current study suggests a potential interaction of obesity and HB-EGF in breast cancer and specifically in triple negative molecular subtype. Further studies could enhance our findings and designate these factors as prognostic biomarkers in breast cancer and especially in triple negative breast cancer (TNBC).
Main subject category:
Health Sciences
Keywords:
Angiogenesis, Triple negative breast cancer
Number of references:
251
File:
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