Unit:
Department of ChemistryLibrary of the School of Science
Author:
Stavropoulou Anastasia
Dissertation committee:
Ευθυμιάδου Ελένη, Αναπ. Καθηγήτρια Τμήμα Χημείας ΕΚΠΑ,
Μητσοπούλου Χριστίνα-Άννα, Καθηγήτρια Τμήμα Χημείας ΕΚΠΑ,
Μεθενίτης Κωσταντίνος, Αναπ. Καθηγητής Τμήμα Χημείας ΕΚΠΑ,
Κυρίτσης Παναγιώτης, Καθηγητής Τμήμα Χημείας ΕΚΠΑ,
Νεοφύτου Παναγιώτης, Ερευνητής Α’ ΕΚΕΦΕ «Δημόκριτος»
Μάρκου Αθηνά, Επικ. Καθηγήτρια Τμήμα Χημείας ΕΚΠΑ,
Χρονοπούλου Ευαγγελία, Επικ. Καθηγήτρια Γεωπ/κο Πανεπιστήμιο Αθηνών
Original Title:
Σύνθεση πολυλειτουργικών νανοσωματιδίων χρυσού και λιποσωμικών νανοσωματιδίων, τροποποιημένων με πλατίνα και σίδηρο, για διάγνωση και θεραπεία
Translated title:
Synthesis of multifunctional gold and liposomal nanoparticles, functionalized with platinum and iron, for diagnosis and treatment
Summary:
The purpose of the present research is the synthesis, the characterization and
the biological evaluation of metallic and hybrid nanostructure for diagnosis and
therapeutic approach of diseases. The research is separated in two parts, for
the two different diseases, cancer and atherosclerosis.
In the first part, 12 different kinds of metallic nanoparticles were synthesized.
There were gold nanoparticles, gold coated platinum nanoparticles reduced
with citric and ascorbic acid and with 7 different amino acids, iron oxide
nanoflowers and iron-platinum nanoparticles. The nanoparticles were
examined structurally and morphologically and examined biologically
evaluated. Firstly, the biocompatibility was assessed and subsequently the
cellular compatibility in a control and a glioblastoma cell line. They were then
tested for their “theranostic” ability in the brain cancer.
In the second part, liposomal nanoparticles and hybrid nanoparticles were
synthesized for the treatment of atherosclerosis. More specifically
thermosensitive liposomal nanoparticles were synthesized in which magnetic
nanoflowers were encapsulated along with two different statins. They were
evaluated for their biocompatibility and afterwards they were tested for their
ability to reduce oxidative stress on the HUVEC cell line, so as to be observed
for their ability to reduce the oxidative stress caused by the disease.
Main subject category:
Science
Keywords:
nanoparticles, platinum, iron, iron oxide magnetic nanoflowers, liposomes, cancer, glioblastoma, statins, atherosclerosis
Number of references:
230
File:
File access is restricted until 2026-03-12.
ΔΙΔΑΚΤΟΡΙΚΟ ΑΝΑΣΤΑΣΙΑ final.pdf
3 MB
File access is restricted until 2026-03-12.
