Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Ρηγόπουλος Δημήτριος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Στρατηγός Αλέξανδρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κατούλης Αλέξανδρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπαδαυίδ Ευαγγελία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικολαίδου Ηλέκτρα, Καθηγήτρια , Ιατρική Σχολή, ΕΚΠΑ
Γρηγορίου Σταμάτης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικολάου Βασιλική, Επίκουρη Καθηγήτρια , Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διερεύνηση της συννοσηρότητας λοίμωξης από τους ιούς των ανθρωπίνων θηλωμάτων και άλλων παθογόνων μικροοργανισμών που μεταδίδονται δια της σεξουαλικής επαφής σε δείγμα γυναικών που προσέρχονται στο ιατρείο σεξουαλικώς μεταδιδομένων νοσημάτων και σε ασυμπτωματικές γυναίκες
Translated title:
Prevalence of cervicovaginal HPV types and other sexually transmitted pathogens in anogenital warts patients in an STD unit
Summary:
There is no longer any doubt today regarding the causative role of Human Papillomavirus (HPV) in the carcinogenesis of the cervix but also in the vagina, vulva, and perianal region.
Especially in the cervix, it has been proven that in more than 99% of cancers, there is a coexistence of infection with high-risk HPV types. Carcinogenesis usually begins in the metaplastic epithelium of the cervix. However, despite exposure to high-risk HPV being a common phenomenon, cervical cancers are relatively rare. For this reason, it is considered that high-risk HPV is necessary for carcinogenesis but is not sufficient on its own. Other factors must coexist to develop precancerous changes that, after a relatively long period, progress to invasive cancer.
The increased frequency of precancerous changes in the cervix in women with a weakened immune system proves that the role of a healthy immune system is crucial. Other possible factors include genetic predisposition, infection with other microbial agents, smoking, poor diet, contraceptive pills, and multiple pregnancies.
Both the formation of precancerous changes in the cervix and their progression to invasive cancer are time-consuming processes. Usually, several years or even decades are required.
A large portion of epithelial cancers in the vulva, vagina, and perianal region also develops after infection with high-risk HPV.
Given these scientific data, the detection of high-risk HPV and other sexually transmitted agents (chlamydia, mycoplasma, ureaplasma, and fungi) in the cervix was considered appropriate for women who were examined at the department of Sexually Transmitted Diseases of the 'Andreas Syggros' Hospital.
Main subject category:
Health Sciences
Keywords:
HPV, Condyloma accuminata, Sexually transmitted diseases, Cervical cancer, Chlamydia trachomatis, Mycoplasma, Ureaplasma
Number of references:
183
File:
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ΜΟΡΤΑΚΗ ΔΕΣΠΟΙΝΑ_ΔΙΔΑΚΤΟΡΙΚΗ ΔΙΑΤΡΙΒΗ.pdf
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