Unit:
Library of the School of Health SciencesΠΜΣ Νεοπλασματική Νόσος στον Άνθρωπο: Έρευνα και Κλινικοπαθολογοανατομική Προσέγγιση στα Πλαίσια της Εξατομικευμένης Ιατρικής (Διάγνωση και Στοχευμένη Θεραπεία)
Author:
Trikoupis Nikolaos
Supervisors info:
Σακελλαρίου Στρατηγούλα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή ΕΚΠΑ
Θυμαρά Ειρήνη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή ΕΚΠΑ
Λακιωτάκη Ελευθερία, Επίκουρη Καθηγήτρια, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Στοχευμένη θεραπεία για την αντιμετώπιση του γαστρικού καρκίνου
Translated title:
Targeted therapeutic options for gastric cancer
Summary:
In this paper, a literature review on the treatment of gastric cancer is presented with emphasis on targeted therapy. Initially, the epidemiological data of the disease and its histological classification are reported. Then, the tools that contribute to the diagnosis of gastric cancer and the techniques to promote prevention are presented. Regarding the treatment of gastric cancer, reference is made to surgical resection, radiation, chemotherapy and immunotherapy. Each treatment option can be used either as monotherapy or in combination depending on the stage of the disease. Concerning targeted therapy, three key biomarkers (HER2, VEGF, PD-1/PD-L1) are examined and how they contribute to the progression of gastric cancer treatment. Finally, the challenges in gastric cancer treatment and future directions are discussed.
Main subject category:
Health Sciences
Keywords:
Gastric cancer, HER2, VEGF, PD-1/PD-L1, Trastuzumab
Number of references:
174
