Unit:
Κατεύθυνση Νεοπλασματική Νόσος στον Άνθρωπο: Έρευνα και Κλινικοπαθολογοανατομική Προσέγγιση στα Πλαίσια της Εξατομικευμένης Ιατρικής (Διάγνωση και Στοχευμένη Θεραπεία)Library of the School of Health Sciences
Author:
Andriopoulos Dimitrios
Supervisors info:
Θεοχάρης Σταμάτιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καραμούζης Μιχαήλ, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τσουρούφλης Γεράσιμος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Εξωσώματα και αντοχή στην χημειοθεραπεία στον καρκίνο του μαστού
Translated title:
Exosomes and chemotherapy resistance in breast cancer
Summary:
Breast cancer constitutes the most frequent malignancy globally and while it is considered curable if detected at an early stage, the prognosis for advanced cases remains poor. Despite the advent of tailored medicine and precision oncology, most cancers will initially respond to treatment and then inevitably relapse/progress. Chemoresistance, which can manifest as de novo or acquired, is a major issue that hinders our therapeutic attempts. Exosomes are microvesicles that stem from the inward budding of the cell membrane, are derived from the endosomal pathway and are dysregulated in cancer. They can be isolated from all tissues and biological fluids and their contents reflect the cell of origin. Their cargo consists of proteins, lipids, DNA, mRNA, and non-coding RNA. In this review, we will attempt to explore how exosomes, can transport their cargo to recipient breast cancer cells and induce chemoresistance. We will mainly focus on the horizontal transfer of proteins, miRNAs and lncRNAs establishing their value as a potential future predictive biomarker.
Main subject category:
Health Sciences
Keywords:
Βreast cancer, Microvesicles, Exosomes, Chemoresistance
