Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Tryfou Thomai-Marina
Dissertation committee:
Κυρτσώνη Μαρία-Χριστίνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κοκόρη Στυλιανή, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Τσαντές Αργύριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παναγιωτίδης Παναγιώτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κοντοπίδου Φλώρα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δεδούσης Γεώργιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καστρίτης Ευστάθιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διαταραχές αιμόστασης σε κακοήθη αιματολογικά νοσήματα
Translated title:
Disorders of hemostasis in hematologic malignancies
Summary:
Patients with malignant hematological diseases show quite often haemostasis disorders that connect with increased morbidity and mortality. Haemostasis is a mechanism triggered by vascular damage, in order to control the bleeding and repair the damage. It is characterized by a rapid response that involves vasoconstriction, platelet activation, aggregation and coagulation cascade activation,that leads finally to clots formation. As soon as the clot is organized, antithrombotic mechanisms are triggered to prevent excess fibrin accumulation. A defect on any stage to this mechanism may lead to clinically significant bleeding or thrombotic disorder. The clinician has to diagnose, undertake and treat a possible coagulopathy, involving the medical history, clinical examination and laboratory investigations. In the present work we approach the coagulation mechanisms and we describe malignant hematological diseases, which often present as: “Complex disorders of blood clotting”. In the experimental part we approach the range of action of phospholipids (plasmogen) and other factors (Von Willebrand), as important mechanisms of haemostasis disorder in samples of patients with malignant haematological diseases with a wide overview to early diagnosis and treatment. Comparison of the various population was made between samples collected at the time of diagnosis with those who collected at molecular remission. All the potential sides of heamostasis were taken under account from laboratory standpoint. Preliminary data suggest that this approach is feasible.
Main subject category:
Health Sciences
Keywords:
Von Willebrand, Phospholipids, Hemostasis, Bleeding, Thrombosis
Number of references:
1069
File:
File access is restricted until 2025-03-27.
Τρύφου Θωμαή Μαρίνα διατριβή τελικό.pdf
12 MB
File access is restricted until 2025-03-27.
