Κατεύθυνση Παιδιατρική Λοιμωξιολογία
Library of the School of Health Sciences

2024-03-21

2024

Mani Marialena

Βασιλική Παπαευαγγέλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Αλεξάνδρα Σολδάτου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γεωργία Γκιούλα, Καθηγήτρια, Ιατρική Σχολή, ΑΠΘ

Ηπατίτιδα Ε σε παιδιά αυξημένου κινδύνου

Greek

Hepatitis E in high risk children

Introduction/Purpose: Hepatitis E virus infection is a common cause of acute viral hepatitis worldwide. It is self-limiting in immunocompetent patients, but in immunosuppressed and pregnant women it is associated with chronicity and complications. The purpose of the present study was to systematically review the literature on HEV IgG prevalence in special groups of children (multitransfused, immunocompromised, chronic liver disease) and in those without comorbidities
Method: 88 articles with HEV IgG Abs in healthy children (24 exclusively with children) and 14 with the corresponding percentages in special groups (11 exclusively with children) were studied.
Results: Anti HEV IgG prevalence in healthy children by continent was: Africa 14.6%, Oceania 9.3%, Asia 7.7%, South America 6.08%, Europe 4%, North America 1.95%. In the special population it ranged from 0.4 to 86%. 67% of the articles concerned solid organ transplant patients. 9 cases of chronic hepatitis were found. Two developed cirrhosis and one mild fibrosis. For those with available data, they were due to genotype 3 and achieved viral clearance with ribavirin.
Conclusion: 2.2% of susceptible children developed chronic hepatitis. Although the risk of developing chronic HEV infection in patients with underlying immunosuppression is small, increased awareness is needed for early diagnosis and treatment.

Health Sciences

Hepatitis E, ΗΕV, Children, Παιδιά, Transplantation, Ηemoglobinopathy

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/3392736