Unit:
Κατεύθυνση Ογκολογία Θώρακα: Σύγχρονη Κλινικο-Εργαστηριακή Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Supervisors info:
Μαρία Τόλια, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Κυριακή Ταβερναράκη, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Γκιόζος, ΑκαδημαΪκός Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μέθοδοι απεικόνισης με τις οποίες μπορούμε να βοηθήσουμε στον σχεδιασμό της ακτινοθεραπείας και στην αποφυγή νευροτοξικότητας σε ασθενείς με καρκίνο πνεύμονα
Translated title:
Imaging methods with which we can assist in organizing radiotherapy programme and avoiding neurotoxicity in patients with lung cancer diagnosis
Summary:
Introduction: Lung cancer is a leading cause of death from malignancy. The majority of patients require radiotherapy, which inhibits the proliferation of malignant cells. However, it also affects the surrounding healthy tissues causing complications.
Aim: To report imaging methods that contribute to the optimal planning of the radiotherapy plan and allow the elimination of treatment toxicity.
Material – Methods: Systematic search of Pubmed, Science Direct, Medline and Embase over the last ten years to identify articles and randomized studies published in English.
Results: Performed 18F-FDG-PET/CT imaging, gold standard test for accuracy of the field to irradiate. In addition to the macroscopic volume, subclinical disease, lesion motion due to respiration by continuous waveform recording with both 4DMRI and 4DPET/CT techniques, possible systemic defects and organs at risk should be assessed. MRI or MRI/PET is performed, as well as magnetic resonance spectroscopy providing variable doses to different parts of the tumour. In addition, due to 18F-FDG accumulation in inflammatory cells as well, tracers of tumor hypoxia (18F-FMISO, 18F-FAZA) and dissemination (18F-FLT) were studied. Finally, MRI 7Tesla was investigated in defining the target tumor by imaging micro angioversion.
Conclusions: Many lung cancer patients require radiotherapy, which causes complications. To minimize these, the treatment plan is determined by imaging methods of specific protocols. Finally, multiple techniques have been developed to target the lesion while protecting healthy tissues, and new ones are being studied
Main subject category:
Health Sciences
Keywords:
Lung cancer, Radiotherapy, Complications, Neurotoxicity, Brain imaging
Number of references:
137
File:
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ΠΤΥΧΙΑΚΗ MSC ΔΙΟΝΕΛΛΗ ΤΕΛΙΚΗ ΜΟΡΦΗ-1-1.pdf
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