Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences

2024-03-27

2024

Karagiannopoulos Asimakis

Χαράλαμπος Χρέλιας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Περικλής Παναγόπουλος, Επικ. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Παπαντωνίου, Ομ. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Αυτοάνοσα νοσήματα της μητέρας και κύηση

Greek

Maternal autoimmune diseases and pregnancy

Introduction: An autoimmune disease (AID) is characterized by tissue damage, which is caused by autoimmunity to different mechanisms of the immune system, namely antibodies and T cells. Its appearance may be related to genetic and / or environmental predisposition. It is determined by the activation of the immune response with consequent tissue damage and inflammation in the absence of any infection, exposure to toxins or tumor growth. Although, individually, each AID affects a small number of individuals, as a whole, its prevalence is estimated to be between 7.6 and 9.4%.
Purpose - Materials and Method: The purpose of this study is to analyse the relationship between the pregnancy process and systemic/organ-specific autoimmune diseases and assess pathological and treatment implications.
Conclusions: An autoimmune disease is characterized by tissue damage, caused by self-reactivity of different effector mechanisms of the immune system, namely antibodies and T cells. During pregnancy, there are significant changes in the mother's immune system and mainly a change in cellular to humoral immunity. Pregnancy changes of the immune system can influence the progression of autoimmune diseases. As described in literature, a strong association between autoimmune disease and obstetric complications was found, especially with systemic lupus erythematosus, antiphospholipid syndrome and autoimmune thyroiditis. The relationship between autoimmunity and reproduction is bidirectional. All AIDs, to some extent, affect fertility and pregnancy.
Currently, due to available treatments and specialised care for pregnant women with autoimmune disease, the prognosis for both mother and infant has improved significantly. However these pregnancies are always high risk.

Health Sciences

Autoimmune disease, Pregnancy, Fertility, Miscarriage, Systemic lupus erythematosus, Antiphospholipid syndrome, Polymyositis, Autoimmune thyroiditis, Vasculitis

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https://pergamos.lib.uoa.gr/uoa/dl/object/3392929