Unit:
Κατεύθυνση Νεοπλασματική Νόσος στον Άνθρωπο: Έρευνα και Κλινικοπαθολογοανατομική Προσέγγιση στα Πλαίσια της Εξατομικευμένης Ιατρικής (Διάγνωση και Στοχευμένη Θεραπεία)Library of the School of Health Sciences
Supervisors info:
Γεώργιος Αγρογιάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ειρήνη Θυμαρά, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Νέo-επικoυρική ακτινoθεραπεία σε σαρκώματα μαλακών μoρίων
Translated title:
Neoadjuvant radiotherapy in soft tisue sarcomas
Summary:
Soft tissue sarcoma (STS) is a rare type of malignant neoplasm, accounting for 1% of new cancer cases in the United States. They manifest as the growth of abnormal cells in the soft tissues of the body. Over 50 histological types of soft tissue sarcomas are described based on the recent World Health Organization (WHO) classification.
The great heterogeneity of this group makes their histological diagnosis difficult. The therapeutic intervention for each patient depends on the histological type, grade of histological malignancy, size, anatomical location and growth rate of the STS from which he/she suffers. The main treatment of these is surgical resection. The contribution of radiotherapy is crucial in the local control of the disease. Chemotherapy is the main therapeutic option in metastatic sarcomas.
In neoadjuvant radiotherapy in STS, a smaller total dose of radiation volume is administered, resulting in a shorter total radiation time. The irradiation field is smaller resulting in less toxicity occurring from normal tissues. However, the risk of developing complications from surgical wound healing is increased. In patients undergoing neoadjuvant radiotherapy there is an increase in local control, an increase in disease-free interval and higher rates of achieving resection at healthy margins in subsequent surgical excision of the tumor.
The aim of this thesis is to collect and present the latest data on the use of neoadjuvant radiotherapy in STS.
Main subject category:
Health Sciences
Keywords:
Neoadjuvant, Radiotherapy, Soft tissue sarcomas, External beam radiation therapy, Surgery
Number of references:
179
