Κατεύθυνση Περιβάλλον και Υγεία: Διαχείριση Περιβαλλοντικών Θεμάτων με Επιπτώσεις στην Υγεία
Library of the School of Health Sciences

2024-04-09

2024

Meidanis Ioannis

Πολυξένη Νικολοπούλου-Σταμάτη, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Ανδρέας Χ. Λαζάρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννα Γιαννοπούλου, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ

Συσχέτιση του καρκίνου κεφαλής και τραχήλου με περιβαλλοντικούς παράγοντες

Greek

Correlation of head and neck cancer with environmental factors

Head and neck cancer refers to a number of different malignant tumors that develop in or around the neck, the pharynx, the larynx, the nose, the sinuses and the mouth. Anatomically, it is subdivided into cancer of the oral cavity, oropharynx, hypopharynx, larynx, nasopharynx, salivary glands and paranasal sinuses. It mainly affects people in densely populated, developing and industrialized countries. The most common malignancy is squamous cell carcinoma, while high risk factors are smoking, alcohol consumption and HPV/EBV infection. Today, environmental pollutants are studied as emerging risks in its development, distribution, evolution and response to treatment. The purpose of this work is to investigate the environmental factors that may be associated with the occurrence of head and neck cancer. In addition to the best-studied risk factors such as tobacco and alcohol, environmental pollutants are an emerging risk for the development and progression of head and neck cancer. Cancer is caused in part by changes in certain genes and, in some cases, can result directly from environmental exposures that lead to DNA damage. Air pollutants and particulate matter pose risks for head and neck cancer. Exposure to nickel, chromium, and cadmium and arsenic compounds have been associated with cancers of the oropharynx and the nasopharynx. Occupational exposure to heavy metals carries an increased risk for head and neck cancers, although epidemiological evidence is limited by methodological problems of the studies. The current literature suggests a lack of data on the clear association of bisphenol-A and head and neck cancer and the clear mechanism underlying the action of bisphenol-A on cancer cells. Exposure to formaldehyde can lead to head and neck tumors. However, the mechanisms underlying formaldehyde-related tumor genesis are very complex. Similarly, nutritional factors, exposure to ionizing and cosmic radiation as well as commonly used dental materials such as acrylics and composite resins are strongly associated with head and neck carcinogenesis. Environmental factors also support and enhance head and neck cancer metastasis by several biological mechanisms. Additional studies are needed to confirm the association of several suspected factors, occupations, and industries with cancers of the oral cavity, pharynx, and nasopharynx. As the science of biology and oncology advances, the association of the environment with the occurrence of head and neck cancer will be better understood, to the benefit of groups, communities, and health care systems.

Health Sciences

Head and neck cancer, Environmental factors, Oral cancer, Squamous cell carcinoma, Laryngeal cancer, Pharyngeal cancer, Nasal and paranasal sinus cancer, Oral premalignant lesions, Environmental pollution, Oxidative stress, Epigenetic modifications, Smoking, Alcohol, Oral microbiome, Nutrition, Particulate matter, Heavy metals, Occupational exposure, Formaldehyde, Radiation, Endocrine disruptors, Bisphenol A, Dental materials.

No

0

Yes

173

77

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/3395974