Unit:
Κατεύθυνση Ανάπτυξη Νέων Φαρμάκων: Έρευνα, Κυκλοφορία και ΠρόσβασηLibrary of the School of Health Sciences
Supervisors info:
Ηλίας Κοττέας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γαρυφαλλιά Πουλάκου, Αναπληρώτρια Καθηγήτρια,Ιατρική Σχολή,ΕΚΠΑ
Ιωάννης Γκιόζος,Ακαδημαικός Υπότροφος,Ιατρική Σχολή,ΕΚΠΑ
Original Title:
Covid-19: Σύγχρονες και αναδυόμενες θεραπευτικές προσεγγίσεις
Translated title:
Covid-19: current and emerging treatments
Summary:
The present study aims to study Covid-19 and more specifically the emerging and emerging therapeutic approaches. The study method was based on the method of literature analysis. For this purpose, the recent international bibliography in the Google Scholar and Science Direct databases was searched. The words used were: covid-19, therapeutic methods, pandemic. From the search results stachy articles of the last five years.
The study concludes that the COVID-19 pandemic has required an effective treatment protocol from researchers and clinicians around the world. At present, a large number of primary data have been generated from various preclinical studies. At least 300 clinical trials are underway to reuse COVID-19 drugs. the clinician needs objective evidence-based medication to treat COVID-19.
The SARS-CoV-2 monoclonal viral RNA encodes structural proteins (spike protein), non-structural enzyme proteins (RNA-dependent RNA polymerase, helix, papain-type protease, other 3-juice type proteases) and others. These four enzymatic proteins in the spike protein are steps in slowing down its replication and, therefore, an attractive target for the development of anti-SARS-CoV-2 drugs.
In silico and in vitro studies have identified several possible epitopes as candidate sequences for vaccine development. These studies have also revealed potential targets for drug development and reuse of COVID-19 drugs..
The COVID-19 pandemic has put enormous pressure on researchers to evaluate and approve effective drugs against the disease. Well-controlled randomized trials should evaluate over-the-counter drugs with substantial indications of safety and efficacy and a greater emphasis on time-tested approaches to drug evaluation.
Main subject category:
Health Sciences
Keywords:
Covid-19, Treatments
File:
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ΔΙΠΛΩΜΑΤΙΚΗ FINAL.pdf
2 MB
File access is restricted only to the intranet of UoA.
