Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Supervisors info:
Σταύρος Σοφοκλής, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ποτήρης Αναστάσιος, Ακαδημαϊκός Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η θέση της πρωτεομικής στην κατανόηση της πρωτεϊνικής έκφρασης του ενδομητρίου γυναικών με επαναλαμβανόμενες αποτυχίες εμφύτευσης
Translated title:
The contribution of proteomics in understanding endometrial protein expression in women with recurrent implantation failure
Summary:
Implantation is an extremely complex biological process, the mechanisms of which are still not fully understood by the scientific community. However, it has been proven that it depends on a variety of factors which must act harmoniously and coordinate with each other, in order to successfully implant the embryo. The main factors that participate and influence the outcome of implantation are the endometrium and the embryo, which is normally at the blastocyst stage, as well as the synchronized biochemical dialogue between them.
The implantation of the embryo is of decisive importance for the success of IVF. Recurrent implantation failure (RIF) is one of the most challenging and complex clinical phenomena that can be caused by maternal, paternal and fetal factors, as well as a combination of different factors. Despite the extensive research and suggestions that have been made for the correct diagnosis, prognosis and various treatment options for RIF, there are still knowledge gaps that need further investigation.
Proteomic analysis has been widely applied in modern research, which aims to gain a deeper understanding of the pathology of recurrent implantation failure and to find reliable biomarkers of endometrial receptivity. From the total of proteomic studies mentioned in this thesis, which focus both on the analysis of endometrial biopsies and on the analysis of endometrial fluid, several proteins that are considered to be related to endometrial receptivity have been identified. Nevertheless, the results between the studies show several variations, which are most likely due to the different experimental conditions of the individual studies.
In conclusion, the use of proteomics can significantly contribute to the treatment of recurrent implantation failure by offering deeper understanding of endometrial protein expression and finding biomarkers of endometrial receptivity. However, it is necessary to establish a common ground in the design of proteomic and bioinformatic analysis experiments. It is also very important to conduct multicenter, prospective and randomized clinical studies, in order to validate the most reliable biomarkers and establish their clinical application, with the ultimate goal of improving embryo implantation rates after IVF.
Main subject category:
Health Sciences
Keywords:
Implantation, Recurrent implantation failure (RIF), Proteomics, Biomarkers of endometrial receptivity
Number of references:
148
File:
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Alyfanti_Eleni_MSc.pdf
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File access is restricted only to the intranet of UoA.
